Rabbit Rho GDP dissociation inhibitor (GDI) gamma Polyclonal Antibody | anti-ARHGDIG antibody
Rabbit anti-human Rho GDP dissociation inhibitor (GDI) gamma polyclonal Antibody
WB: 1:500-1:5000
IHC: 1:50-1:200(Recommender dilutions)
Positive WB detected in: HeLa cells, HEK-293 cells, human brain tissue, MCF-7 cells
Positive IHC detected in: Human pancreas cancer tissue
Function: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP-and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
NCBI and Uniprot Product Information
NCBI Description
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Uniprot Description
RhoGDI gamma: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP. Belongs to the Rho GDI family.
Protein type: Inhibitor; Motility/polarity/chemotaxis; G protein regulator, misc.; Cell adhesion
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: membrane; cytoplasmic membrane-bound vesicle; cytosol
Molecular Function: Rho GDP-dissociation inhibitor activity; GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction; regulation of protein localization; small GTPase mediated signal transduction; negative regulation of cell adhesion; Rho protein signal transduction; positive regulation of GTPase activity
Research Articles on ARHGDIG
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Product Notes
The ARHGDIG arhgdig (Catalog #AAA710991) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Rho GDP dissociation inhibitor (GDI) gamma polyclonal Antibody reacts with Human, Mouse,Rat; Other species are not tested. Please decide the specificity by homology. and may cross-react with other species as described in the data sheet. AAA Biotech's Rho GDP dissociation inhibitor (GDI) gamma can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: Use at an assay dependent dilution. WB: 1:500-1:5000 IHC: 1:50-1:200(Recommender dilutions) Positive WB detected in: HeLa cells, HEK-293 cells, human brain tissue, MCF-7 cells Positive IHC detected in: Human pancreas cancer tissue. Researchers should empirically determine the suitability of the ARHGDIG arhgdig for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Rho GDP dissociation inhibitor (GDI) gamma, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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