Rabbit anti-Human KCNAB1 Polyclonal Antibody | anti-KCNAB1 antibody

KCNAB1, NT (KCNAB1, KCNA1B, Voltage-gated potassium channel subunit beta-1, K(+) channel subunit beta-1, Kv-beta-1) (Azide free) (HRP)

Cat. Num. AAA6312273

• Gene Names: KCNAB1; hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNAB1; Polyclonal Antibody; NT (KCNAB1; KCNA1B; Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1) (Azide free) (HRP); Kv-beta-1; anti-KCNAB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-KCNAB1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human KCNAB1.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNAB1 Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the KCNAB1 antibody detected the KCNAB1 protein (arrow).)

Related Product Information for anti-KCNAB1 antibody

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.

Product Categories/Family for anti-KCNAB1 antibody

Antibodies; Ion Channel

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Decher, N., et al. EMBO J. 27(23):3164-3174(2008). Cavalleri, G.L., et al. Lancet Neurol 6(11):970-980(2007). Lamesch, P., et al. Genomics 89(3):307-315(2007). Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007).

NCBI and Uniprot Product Information

• NCBI GI #: 27436962
• NCBI GeneID: 7881
• NCBI Accession #: NP_003462.2
• NCBI GenBank Nucleotide #: NM_003471.3
• UniProt Accession #: Q14722; Q13031; Q13302; Q16547; Q6PI60; Q99869; A8K9H8; A8KAD4; B3KPZ4
• Molecular Weight: 45,492 Da
• NCBI Official Full Name: voltage-gated potassium channel subunit beta-1 isoform 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, beta member 1
• NCBI Official Symbol: KCNAB1
• NCBI Official Synonym Symbols: hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1
• NCBI Protein Information: voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; potassium channel beta 3 chain; potassium channel beta3 subunit; potassium channel shaker chain beta 1a; potassium voltage-gated channel beta subunit; voltage-gated potassium cha
• UniProt Protein Name: Voltage-gated potassium channel subunit beta-1
• Protein Family: Voltage-gated potassium channel
• UniProt Gene Name: KCNAB1
• UniProt Synonym Gene Names: KCNA1B
• UniProt Entry Name: KCAB1_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extrinsic to internal side of plasma membrane; plasma membrane; cytosol

Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity; aldo-keto reductase activity

Biological Process: synaptic transmission; learning and/or memory; potassium ion transport