Western Blot (WB)
(Western blot analysis of lysate from human heart tissue lysate, using KCNAB1 Antibody (N-term). MBS9210283 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
Rabbit anti-Human KCNAB1 Polyclonal Antibody | anti-KCNAB1 antibody
KCNAB1 Antibody (N-term)
Western Blot (WB)
(Western blot analysis of lysate from human heart tissue lysate, using KCNAB1 Antibody (N-term). MBS9210283 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
Western Blot (WB)
(Western blot analysis of lysate from human heart tissue lysate, using KCNAB1 Antibody (N-term). MBS9210283 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.)
voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating
neurotransmitter release, heart rate, insulin secretion, neuronal
excitability, epithelial electrolyte transport, smooth muscle
contraction, and cell volume. Four sequence-related potassium
channel genes - shaker, shaw, shab, and shal - have been identified
in Drosophila, and each has been shown to have human homolog(s).
This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member includes three distinct
isoforms which are encoded by three alternatively spliced
transcript variants of this gene. These three isoforms are beta
subunits, which form heteromultimeric complex with alpha subunits
and modulate the activity of the pore-forming alpha subunits.
Decher, N., et al. EMBO J. 27(23):3164-3174(2008)
Cavalleri, G.L., et al. Lancet Neurol 6(11):970-980(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007) :
NCBI and Uniprot Product Information
NCBI Description
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Apr 2015]
Uniprot Description
Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: extrinsic to internal side of plasma membrane; plasma membrane; cytosol
Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity; aldo-keto reductase activity
Biological Process: synaptic transmission; learning and/or memory; potassium ion transport
Research Articles on KCNAB1
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Product Notes
The KCNAB1 kcnab1 (Catalog #AAA9210283) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 15-44. The KCNAB1 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KCNAB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the KCNAB1 kcnab1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNAB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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