Rabbit KCNAB1/Kv beta 1 Polyclonal Antibody | anti-KCNAB1/Kvbeta1 antibody

KCNAB1/Kv beta 1 Polyclonal Antibody

Cat. Num. AAA3005592

• Gene Names: KCNAB1; hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1
• Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: KCNAB1/Kv beta 1; Polyclonal Antibody; KCNAB1/Kv beta 1 Polyclonal Antibody; hKvb3; hKvBeta3; K(+) channel subunit beta-1; KCAB1_HUMAN; KCNA1B; KCNAB1; KV-BETA-1; Kvb1.3; Voltage-gated potassium channel beta-1 subunit; Voltage-gated potassium channel subunit beta-1; anti-KCNAB1/Kvbeta1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep
• Clonality: Polyclonal
• Specificity: KCNAB1/Kv beta 1 Polyclonal Antibody detects endogenous levels of KCNAB1/Kv beta 1 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-KCNAB1/Kvbeta1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from human KCNAB1/Kv beta 1:131-230/419
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Primary: Anti-KCNAB1’Kv beta 1 at 1/500 dilution)

Testing Data

(Primary: Anti-KCNAB1’Kv beta 1 at 1/1000 dilution)

Related Product Information for anti-KCNAB1/Kvbeta1 antibody

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming å subunits (KV), which include the KV1, KV2, KV3 and KV4 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV?, also known as KCNAB1 (potassium voltage-gated channel, shaker-related subfamily, beta member 1), is a 419 amino acid accessory K+ channel protein that exists as three alternatively spliced isoforms and regulates the activity of the pore-forming å subunit. It is expressed in brain, with highest levels detected in caudate nucleus, hippocampus and thalamus.

NCBI and Uniprot Product Information

• NCBI GI #: 27436962
• NCBI GeneID: 7881
• NCBI Accession #: NP_003462.2
• NCBI GenBank Nucleotide #: NM_003471.3
• UniProt Accession #: Q14722; Q13031; Q13302; Q16547; Q6PI60; Q99869; A8K9H8; A8KAD4; B3KPZ4
• Molecular Weight: 45,492 Da
• NCBI Official Full Name: voltage-gated potassium channel subunit beta-1 isoform 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, beta member 1
• NCBI Official Symbol: KCNAB1
• NCBI Official Synonym Symbols: hKvb3; AKR6A3; KCNA1B; Kvb1.3; hKvBeta3; KV-BETA-1
• NCBI Protein Information: voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; potassium channel beta 3 chain; potassium channel beta3 subunit; potassium channel shaker chain beta 1a; potassium voltage-gated channel beta subunit; voltage-gated potassium cha
• UniProt Protein Name: Voltage-gated potassium channel subunit beta-1
• UniProt Gene Name: KCNAB1
• UniProt Synonym Gene Names: KCNA1B
• UniProt Entry Name: KCAB1_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: extrinsic to internal side of plasma membrane; plasma membrane; cytosol

Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity; aldo-keto reductase activity

Biological Process: synaptic transmission; learning and/or memory; potassium ion transport