Mouse anti-Human NTB-A Monoclonal Antibody | anti-SLAMF6 antibody
NTB-A (SLAMF6, SLAM family member 6, Activating NK receptor, KALI, KALIb, Ly108, MGC104953, NK-T-B-antigen, NTBA, SF2000, UNQ6123/PRO20080) (Carboxyfluorescein)
Gene Names
SLAMF6; KALI; NTBA; KALIb; Ly108; NTB-A; SF2000; FLJ50657; MGC104953; SLAMF6
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
PurifiedPurified immunoglobulin
Synonyms
NTB-A; Monoclonal Antibody; NTB-A (SLAMF6; SLAM family member 6; Activating NK receptor; KALI; KALIb; Ly108; MGC104953; NK-T-B-antigen; NTBA; SF2000; UNQ6123/PRO20080) (Carboxyfluorescein); Anti -NTB-A (SLAMF6; anti-SLAMF6 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
7H16
Specificity
Recognizes human NTB-A/SLAMF6.
Purity/Purification
Purified
Purified immunoglobulin
Purified immunoglobulin
Form/Format
Supplied as a liquid. Labeled with Carboxyfluorescein.
Applicable Applications for anti-SLAMF6 antibody
Flow Cytometry (FC/FACS)
Application Notes
Suitable for use in Flow Cytometry.
Immunogen
Human NTB-A/SLAMF6
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-SLAMF6 antibody
NTB-A is a type I transmembrane protein belonging to the SLAM family of immune cell receptors and has been designated SLAMF6. The SLAM family proteins are members of the CD2 subgroup of the Ig superfamily. NTB-A is expressed on NK-, T-, and B cells. NTB-A exhibits homotypic interactions and can associate with adaptor molecules such as SAP to modulate immune cell functions.
Product Categories/Family for anti-SLAMF6 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
37,345 Da
NCBI Official Full Name
NTB-A receptor
NCBI Official Synonym Full Names
SLAM family member 6
NCBI Official Symbol
SLAMF6
NCBI Official Synonym Symbols
KALI; NTBA; KALIb; Ly108; NTB-A; SF2000; FLJ50657; MGC104953; SLAMF6
NCBI Protein Information
SLAM family member 6; NTBA receptor; NK-T-B-antigen; OTTHUMP00000024349; activating NK receptor; natural killer-, T- and B-cell antigen
UniProt Protein Name
SLAM family member 6
Protein Family
UniProt Gene Name
SLAMF6
UniProt Synonym Gene Names
KALI
UniProt Entry Name
SLAF6_HUMAN
NCBI Description
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Uniprot Description
SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: integral to membrane; plasma membrane
Molecular Function: receptor activity
Research Articles on SLAMF6
1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
2. Observational study of gene-disease association. (HuGE Navigator)
3. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]
4. HTLV-1-infected CD4+ T cells did not express ligands for NK cell activating receptors, NCR and NKG2D, although they did express ligands for NK cell coactivating receptors, NTB-A and 2B4.
5. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A.
6. regulation of interferon-gamma secretion, and not interleukin-4 in vitro, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response
7. blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity
8. NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.
9. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2
2. Observational study of gene-disease association. (HuGE Navigator)
3. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]
4. HTLV-1-infected CD4+ T cells did not express ligands for NK cell activating receptors, NCR and NKG2D, although they did express ligands for NK cell coactivating receptors, NTB-A and 2B4.
5. The 3.0 A crystal structure of the complete NTB-A ectodomain revealed a rod-like monomer that self-associates to form a highly kinked dimer spanning an end-to-end distance of approximately 100 A.
6. regulation of interferon-gamma secretion, and not interleukin-4 in vitro, as well as inhibition of Th1 cell-induced isotype switching and attenuation of experimental allergic encephalomyelitis identifies NTB-A as a regulator of T cell response
7. blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity
8. NTB-A is an interlymphocyte signaling molecule, which serves to orchestrate the activities of immune cells.
9. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2
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Product Notes
The SLAMF6 slamf6 (Catalog #AAA603736) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NTB-A (SLAMF6, SLAM family member 6, Activating NK receptor, KALI, KALIb, Ly108, MGC104953, NK-T-B-antigen, NTBA, SF2000, UNQ6123/PRO20080) (Carboxyfluorescein) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NTB-A can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry. Researchers should empirically determine the suitability of the SLAMF6 slamf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NTB-A, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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