SLAM Family Member 6/SLAMF6/CD352/NTB-A) Biotinylated Recombinant Protein | SLAM recombinant protein

Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His-Avi) Biotinylated

Cat. Num. AAA2569204

• Gene Names: SLAMF6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: SLAM Family Member 6/SLAMF6/CD352/NTB-A) Biotinylated; Recombinant Human SLAM Family Member 6/SLAMF6/CD352/NTB-A (C-6His-Avi) Biotinylated; SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI; SLAM recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Gln22-Lys225

• Species: Human
• Tag: C-6His-Avi
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Biotinylated Recombinant Human SLAM Family Member 6 is produced by our Mammalian expression system and the target gene encoding Gln22-Lys225 is expressed with a 6His, Avi tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for SLAM recombinant protein

SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN-gamma by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.

Product Categories/Family for SLAM recombinant protein

immunology

NCBI and Uniprot Product Information

• NCBI GI #: 296040491
• NCBI GeneID: 114836
• NCBI Accession #: NP_001171643.1
• NCBI GenBank Nucleotide #: NM_001184714.1
• UniProt Accession #: Q96DU3; Q14CF0; Q5TAS4; Q5TAS6; Q5TAT3; Q96DV0; A6NMW2; B2R8X8
• Molecular Weight: 24,976 Da
• NCBI Official Full Name: SLAM family member 6 isoform 1
• NCBI Official Synonym Full Names: SLAM family member 6
• NCBI Official Symbol: SLAMF6
• NCBI Official Synonym Symbols: KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000
• NCBI Protein Information: SLAM family member 6; NK-T-B-antigen; NTBA receptor; activating NK receptor; natural killer-, T- and B-cell antigen
• UniProt Protein Name: SLAM family member 6
• UniProt Gene Name: SLAMF6
• UniProt Synonym Gene Names: KALI; NTB-A
• UniProt Entry Name: SLAF6_HUMAN

NCBI Description

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Uniprot Description

SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: receptor activity