EPAC2 positive control
Epac2 Positive Control
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
NCBI and Uniprot Product Information
NCBI Description
bind cAMP and activate the guanine nucleotide binding protein Rap1A [RGD, Feb 2006]
Uniprot Description
RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: GEFs; GEFs, Ras
Cellular Component: apical plasma membrane; axon; basolateral plasma membrane; brush border; cell soma; cilium; cytoplasm; cytosol; dendrite; dendritic spine; excitatory synapse; growth cone; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; protein complex
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein complex binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: brain development; calcium ion-dependent exocytosis; cAMP-mediated signaling; exocytosis; heart development; insulin secretion; negative regulation of synaptic transmission; positive regulation of GTPase activity; positive regulation of protein secretion; positive regulation of smooth muscle cell migration; regulation of dendrite development; regulation of exocytosis; signal transduction; small GTPase mediated signal transduction; spinal cord development
Research Articles on EPAC2
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Product Notes
The EPAC2 rapgef4 (Catalog #AAA542737) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's EPAC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the EPAC2 rapgef4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EPAC2, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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