Western Blot (WB)
Rabbit EPAC1 Polyclonal Antibody | anti-EPAC1 antibody
Epac1 Antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:200
Immunofluorescence: 1:200
Immunohistochemistry: 1:200
Western Blot: 1:500
Sequence: DHSVLTLQLQLPVTASVR
Western Blot (WB)
Western Blot (WB)
Guanine nucleotide exchange factor for RAP1A and RAP2A small GTPases that are activated by binding cAMP
NCBI and Uniprot Product Information
Uniprot Description
Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, misc.; GEFs
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: apical part of cell; basal plasma membrane; brush border membrane; cell soma; cortical actin cytoskeleton; endomembrane system; filopodium; growth cone; lamellipodium; membrane; microvillus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein domain specific binding; Rap guanyl-nucleotide exchange factor activity
Biological Process: angiogenesis; brain development; cAMP-mediated signaling; cell proliferation; negative regulation of collagen biosynthetic process; positive regulation of angiogenesis; positive regulation of cAMP catabolic process; positive regulation of cell size; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription from RNA polymerase II promoter; Rap protein signal transduction; regulation of insulin secretion; response to nicotine; signal transduction; spinal cord development
Research Articles on EPAC1
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Product Notes
The EPAC1 rapgef3 (Catalog #AAA540635) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Epac1 Antibody reacts with Horse, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's EPAC1 can be used in a range of immunoassay formats including, but not limited to, Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). Confocal Microscopy||1:200 Dot Blot: 1:10,000 ELISA: 1:10,000 Immunocytochemistry: 1:200 Immunofluorescence: 1:200 Immunohistochemistry: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the EPAC1 rapgef3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EPAC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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