Immunohistochemistry (IHC)
Rabbit EPAC2 Polyclonal Antibody | anti-EPAC2 antibody
Epac2 Antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:200
Immunofluorescence: 1:200
Immunohistochemistry: 1:200
Western Blot: 1:500
Sequence: CPREQFDSLTPLPEQEGPT
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.
NCBI and Uniprot Product Information
NCBI Description
bind cAMP and activate the guanine nucleotide binding protein Rap1A [RGD, Feb 2006]
Uniprot Description
RAPGEF4: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2. Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: GEFs; GEFs, Ras
Cellular Component: apical plasma membrane; axon; basolateral plasma membrane; brush border; cell soma; cilium; cytoplasm; cytosol; dendrite; dendritic spine; excitatory synapse; growth cone; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; protein complex
Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein complex binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: brain development; calcium ion-dependent exocytosis; cAMP-mediated signaling; exocytosis; heart development; insulin secretion; negative regulation of synaptic transmission; positive regulation of GTPase activity; positive regulation of protein secretion; positive regulation of smooth muscle cell migration; regulation of dendrite development; regulation of exocytosis; signal transduction; small GTPase mediated signal transduction; spinal cord development
Research Articles on EPAC2
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Product Notes
The EPAC2 rapgef4 (Catalog #AAA540020) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Epac2 Antibody reacts with Human, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's EPAC2 can be used in a range of immunoassay formats including, but not limited to, Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Confocal Microscopy||1:200 Dot Blot: 1:10,000 ELISA: 1:10,000 Immunocytochemistry: 1:200 Immunofluorescence: 1:200 Immunohistochemistry: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the EPAC2 rapgef4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EPAC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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