Molecular Structure
LFM-A13, inhibitor
LFM-A13
Purity
98% (TLC: 2:8 CH3OH:CH2Cl2; Rf=0.53); NMR (Conforms)
Synonyms
LFM-A13; GW-441756; 1; 3-Dihydro-3-[(1-methyl-1H-indol-3--yl)methylene]-2H-pyrrolo[3; 2-b]pyridin-2-one; 2-Cyano-N-(2; 5-dibromophenyl)-3-hydroxy-2-butenamide; inhibitor
Purity/Purification
98% (TLC: 2:8 CH3OH:CH2Cl2; Rf=0.53); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
62004-35-7
Molecular Formula
C11H8Br2N2O2
Melting Point
145-146 degree C
Activity
NGFR inhibitor
Reconstitution
May be dissolved in DMSO (25 mg/ml); or Ethanol (100 mg/ml)
Solubilization
DMSO (10 mg/ml) and ethanol (15 mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Molecular Structure
Molecular Structure
Related Product Information for LFM-A13, inhibitor
BTK Inhibitor
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Blocks TrkA-mediated gH2AX production2 and apoptosis3 in TrkA-overexpressing cells. Cell permeable.
Scientific Background: Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM (1) and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM (2).
Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Blocks TrkA-mediated gH2AX production2 and apoptosis3 in TrkA-overexpressing cells. Cell permeable.
Scientific Background: Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM (1) and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM (2).
Product Categories/Family for LFM-A13, inhibitor
References
1. ER Wood et al. Bioorg. Med. Chem. Lett. 2004 14:953 2. EJ Jung et al. Exp. Mol. Med. 2008 40:276 3. EJ Wood et al. Mol. Cells Lett. 2008 26:12
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Product Notes
The LFM-A13 (Catalog #AAA515028) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LFM-A13, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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