Rabbit anti-Human PTGS2 Polyclonal Antibody | anti-PTGS2 antibody

PTGS2 Antibody

Cat. Num. AAA9407431

• Gene Names: PTGS2; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: PTGS2; Polyclonal Antibody; PTGS2 Antibody; COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS; anti-PTGS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total PTGS2 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 2.3 mg/ml (varies by lot)
• Sequence Length: 604

• Applicable Applications for anti-PTGS2 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:30-1:150
• Immunogen Type: Protein
• Immunogen Description: Fusion protein corresponding to residues near the C terminal of human prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
• Target Name: PTGS2
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/40.)

Related Product Information for anti-PTGS2 antibody

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme.

Product Categories/Family for anti-PTGS2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4506265
• NCBI GeneID: 5743
• NCBI Accession #: NP_000954.1
• NCBI GenBank Nucleotide #: NM_000963.3
• UniProt Accession #: P35354; Q16876; A8K802
• Molecular Weight: 68,996 Da
• NCBI Official Full Name: prostaglandin G/H synthase 2
• NCBI Official Synonym Full Names: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
• NCBI Official Symbol: PTGS2
• NCBI Official Synonym Symbols: COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
• NCBI Protein Information: prostaglandin G/H synthase 2
• UniProt Protein Name: Prostaglandin G/H synthase 2
• Protein Family: Prostaglandin G/H synthase
• UniProt Gene Name: PTGS2
• UniProt Synonym Gene Names: COX2; COX-2; PGH synthase 2; PGHS-2
• UniProt Entry Name: PGH2_HUMAN

NCBI Description

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]

Uniprot Description

COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family.

Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1

Chromosomal Location of Human Ortholog: 1q25.2-q25.3

Cellular Component: endoplasmic reticulum membrane; neuron projection; protein complex; cytoplasm; caveola; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; enzyme binding; protein homodimerization activity; peroxidase activity; arachidonate 15-lipoxygenase activity; metal ion binding; heme binding; lipid binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; response to lithium ion; response to glucocorticoid stimulus; response to lipopolysaccharide; positive regulation of NF-kappaB import into nucleus; decidualization; prostaglandin biosynthetic process; sensory perception of pain; positive regulation of synaptic transmission, glutamatergic; negative regulation of synaptic transmission, dopaminergic; response to estradiol stimulus; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; response to vitamin D; lipoxygenase pathway; nicotinamide metabolic process; regulation of blood pressure; negative regulation of smooth muscle contraction; arachidonic acid metabolic process; angiogenesis; positive regulation of smooth muscle contraction; inflammatory response; water-soluble vitamin metabolic process; response to fructose stimulus; positive regulation of prostaglandin biosynthetic process; response to drug; negative regulation of calcium ion transport; vitamin metabolic process; cyclooxygenase pathway; positive regulation of synaptic plasticity; learning; memory; hair cycle; prostaglandin metabolic process; ovulation; response to manganese ion; NAD metabolic process; regulation of inflammatory response; positive regulation of vasoconstriction; brown fat cell differentiation; positive regulation of fever; response to oxidative stress; cell motility; embryo implantation