Related Product Information for anti-COVID-19 antibody
Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus, originated from the Wuhan region of Hubei province in China late in 2019 (1). Coronavirus invades cells through spike protein mediated binding human airway epithelial cell surface receptor Angiotensin converting enzyme 2 (ACE2). Spike protein also mediates fusion of host and viral cell membrane to begin infection (2). Spike protein is the major target for neutralizing antibodies and vaccine development (3).
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain, which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.
Protein modeling suggests that there is a strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (4). A recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (5).
References
1) Gorbalenya. bioRxiv: 2020.
2)Belouzard et al. Viruses. 2012;4(6):1011-33.
3) Lee et al. J Virol. 2006;80(8):4079-87.
4) Wan et al. J Virol. 2020.
5) Wrapp et al. Science. 2020.
Product Notes
The COVID-19 (Catalog #
AAA378287) is an Antibody produced from Chicken and is intended for research purposes only. The product is available for immediate purchase. The SARS-CoV-2 (COVID-19, 2019-nCoV) Spike S1 Domain Antibody reacts with Virus and may cross-react with other species as described in the data sheet. AAA Biotech's COVID 19 Spike S1 Coronavirus can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody can be used for detection of full length SARS-CoV-2 (COVID-19, 2019-nCoV) Spike protein (S1+S2) or truncated SARS-CoV-2 (COVID-19, 2019-nCoV) Spike protein S2 domain by ELISA. Researchers should empirically determine the suitability of the COVID-19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"COVID 19 Spike S1 Coronavirus, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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