Western Blot (WB)
(WB Suggested Anti-TLE3 Antibody Titration: 2.5ug/mlPositive Control: HepG2 cell lysate)
Rabbit TLE3 Polyclonal Antibody | anti-TLE3 antibody
TLE3 antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-TLE3 Antibody Titration: 2.5ug/mlPositive Control: HepG2 cell lysate)
Western Blot (WB)
(WB Suggested Anti-TLE3 Antibody Titration: 2.5ug/mlPositive Control: HepG2 cell lysate)
Target Description: The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Uniprot Description
TLE3: transcriptional corepressor that binds to a number of transcription factors. Belongs to the WD-repeat Groucho/TLE family. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Four alternatively spliced isoforms have been described.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: Notch signaling pathway; organ morphogenesis; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; signal transduction
Research Articles on TLE3
Similar Products
Product Notes
The TLE3 tle3 (Catalog #AAA3200886) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TLE3 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's TLE3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TLE3 tle3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: GSSSGLLALG ALGSQAHLTV KDEKNHHELD HRERESSANN SVSPSESLRA. It is sometimes possible for the material contained within the vial of "TLE3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
