CD24 / Ly-52 / CD24A recombinant protein

Recombinant Rat CD24 / Ly-52 / CD24A Protein (Fc tag)

Cat. Num. AAA2547366

• Gene Names: Cd24; Cd24a
• Purity: > 90 % as determined by SDS-PAGE
• Synonyms: CD24 / Ly-52 / CD24A; Recombinant Rat CD24 / Ly-52 / CD24A Protein (Fc tag); CD24; Cd24a; CD24 / Ly-52 / CD24A recombinant protein

• Host: Human Cells
• Purity/Purification: > 90 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 76

• Application Notes: The recombinant rat CD24/Fc is a disulfide-linked homodimer. The reduced monomer comprises 270 amino acids and has a predicted molecular mass of 29.9 kDa. The apparent molecular mass of the protein is approximately 43-48 kDa in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Asn 27
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

Related Product Information for CD24 / Ly-52 / CD24A recombinant protein

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 24, also known as signal transducer CD24 or heat stable antigen CD24 (HSA), is a mucin-type glycosylphosphatidylinositol-linked glycoprotein expressed on the surface of B-cells, differentiating neuroblasts and many tumors. It is involved in molecular adhesion and metastatic tumor spread and serve as a normal receptor for P-selectin. The CD24 / P-selectin pathway could be important in dissimenating of tumor cells by facilitating the interaction with platelet and endothelial cells. It has also been considered as a tumor marker. High rate of CD24 expressions have been found in epithelial ovarian cancer, breast cancer, non-small cell lung cancer, prostate cancer and pancreatic cancer.

Description: A DNA sequence encoding the rat CD24 (Q07490) (Met1-Cys55) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 6978623
• NCBI GeneID: 25145
• NCBI Accession #: NP_036884.1
• NCBI GenBank Nucleotide #: NM_012752.3
• UniProt Accession #: Q07490; Q0P5T1
• Molecular Weight: 7,862 Da
• NCBI Official Full Name: signal transducer CD24
• NCBI Official Synonym Full Names: CD24 molecule
• NCBI Official Symbol: Cd24
• NCBI Official Synonym Symbols: Cd24a
• NCBI Protein Information: signal transducer CD24
• UniProt Protein Name: Signal transducer CD24
• UniProt Gene Name: Cd24
• UniProt Synonym Gene Names: Cd24a; HSA

NCBI Description

GPI-anchored transmembrane glycoprotein involved in cell-cell adhesion and signaling; may be involved in neuronal migration during development [RGD, Feb 2006]

Uniprot Description

May have a pivotal role in cell differentiation. The triggering mechanism of signal transduction may be due to the interactions of differentiating cells with the matrix substrate via the carbohydrate structure of the molecule. In this way, the signal transducer can play very different roles in different cell types as a direct consequence of its glycosylation.