Immunohistochemistry - Paraffin (IHC)
(Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human C1D Polyclonal Antibody | anti-C1D antibody
Anti-C1D Antibody (aa1-135) IHC-plus
Immunohistochemistry - Paraffin (IHC)
(Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry - Paraffin (IHC)
(Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
Uniprot Description
C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family.
Protein type: Transcription, coactivator/corepressor; Nucleolus; DNA-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 2p13-p12
Cellular Component: cytoplasm; nuclear exosome (RNase complex); nucleolus; nucleus; transcriptional repressor complex
Molecular Function: DNA binding; ligand-dependent nuclear receptor binding; protein binding; RNA binding; transcription corepressor activity
Biological Process: apoptosis; maturation of 5.8S rRNA; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on C1D
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Product Notes
The C1D c1d (Catalog #AAA2400233) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-C1D Antibody (aa1-135) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's C1D can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA). IHC-P (15 ug/ml). Researchers should empirically determine the suitability of the C1D c1d for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "C1D, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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