Signal Transducer CD24/CD24 Recombinant Protein | CD24/CD24 recombinant protein

Recombinant Mouse Signal Transducer CD24/CD24 (C-Fc)

Cat. Num. AAA2569357

• Gene Names: Cd24a; HSA; Cd24; Ly-52; nectadrin
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Signal Transducer CD24/CD24; Recombinant Mouse Signal Transducer CD24/CD24 (C-Fc); Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24; CD24A ; CD24/CD24 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Asn27-Gly53

• Species: Mouse
• Tag: C-Fc
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Signal Transducer CD24 is produced by our Mammalian expression system and the target gene encoding Asn27-Gly53 is expressed with a Fc tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for CD24/CD24 recombinant protein

Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.

NCBI and Uniprot Product Information

• NCBI GI #: 55442
• NCBI GeneID: 12484
• UniProt Accession #: P24807; P26691
• Molecular Weight: 7,797 Da
• NCBI Official Full Name: heat stable antigen
• NCBI Official Synonym Full Names: CD24a antigen
• NCBI Official Symbol: Cd24a
• NCBI Official Synonym Symbols: HSA; Cd24; Ly-52; nectadrin
• NCBI Protein Information: signal transducer CD24
• UniProt Protein Name: Signal transducer CD24
• UniProt Gene Name: Cd24
• UniProt Synonym Gene Names: Cd24a; Ly-52; Ly-52; HSA

Uniprot Description

May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses (). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed:19264983). Plays a role in the control of autoimmunity (PubMed:20200274).