Rabbit anti-Human CDH17  Monoclonal Antibody | anti-CDH17  antibody

Rabbit anti Human CDH17  Monoclonal Antibody

Cat. Num. AAA2544233

• Gene Names: CDH17; HPT1; CDH16; HPT-1
• Reactivity: Human
• Applications: ELISA
• Synonyms: CDH17 ; Monoclonal Antibody; Rabbit anti Human CDH17 Monoclonal Antibody; anti-CDH17 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 832

• Applicable Applications for anti-CDH17 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CDH17. The detection limit for Human CDH17 is approximately 0.078 ng/well.
• Immunogen: Recombinant Human Cadherin-17/LI-cadherin/CDH17 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CDH17  antibody

Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for identification of adenocarcinomas of the digestive system.

NCBI and Uniprot Product Information

• NCBI GI #: 221316595
• NCBI GeneID: 1015
• NCBI GenBank Nucleotide #: NM_001144663.1
• Molecular Weight: 92,219 Da
• NCBI Official Full Name: cadherin-17
• NCBI Official Synonym Full Names: cadherin 17
• NCBI Official Symbol: CDH17
• NCBI Official Synonym Symbols: HPT1; CDH16; HPT-1
• NCBI Protein Information: cadherin-17
• UniProt Protein Name: Cadherin-17
• UniProt Gene Name: CDH17
• UniProt Synonym Gene Names: LI-cadherin
• UniProt Entry Name: CAD17_HUMAN

NCBI Description

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Uniprot Description

CDH17: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: basolateral plasma membrane; plasma membrane

Molecular Function: integrin binding; proton-dependent oligopeptide secondary active transmembrane transporter activity; transporter activity

Biological Process: calcium-dependent cell-cell adhesion; cell adhesion; cell surface receptor linked signal transduction leading to integrin activation; homophilic cell adhesion; integrin-mediated signaling pathway; oligopeptide transport