Rabbit anti-Mouse Estrogen Receptor Beta (ERb) Polyclonal Antibody | anti-ERb antibody
FITC-linked Antibody to Estrogen Receptor Beta (ERb)
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
NCBI and Uniprot Product Information
Uniprot Description
ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Protein type: Nuclear receptor; DNA-binding
Cellular Component: neuron projection; mitochondrion; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; perikaryon; nucleus; cilium
Molecular Function: peroxisome proliferator activated receptor binding; ligand-dependent nuclear receptor activity; estrogen receptor activity; hormone binding; zinc ion binding; metal ion binding; estrogen response element binding; drug binding; steroid binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; lipid binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; estrogen receptor signaling pathway; behavioral fear response; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; induction of apoptosis by hormones; positive regulation of transcription, DNA-dependent; neuron migration; negative regulation of transcription from RNA polymerase II promoter; uterus development; negative regulation of cell proliferation; learning and/or memory; regulation of transcription, DNA-dependent; ovarian follicle development; positive regulation of epidermal growth factor receptor signaling pathway; regulation of neuron apoptosis; negative regulation of epithelial cell proliferation; steroid hormone receptor signaling pathway; transcription, DNA-dependent; vagina development; Sertoli cell proliferation; response to testosterone stimulus; regulation of cell proliferation; steroid hormone mediated signaling; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of behavior
Research Articles on ERb
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Product Notes
The ERb esr2 (Catalog #AAA2016333) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FITC-linked Antibody to Estrogen Receptor Beta (ERb) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Estrogen Receptor Beta (ERb) can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the ERb esr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Estrogen Receptor Beta (ERb), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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