APG7 Blocking Peptide | ATG7 blocking peptide

APG7 Peptide

Cat. Num. AAA151933

• Gene Names: ATG7; GSA7; APG7L; APG7-LIKE
• Applications: Blocking (BL)
• Synonyms: APG7; APG7 Peptide; GSA7; APG7L; APG7-LIKE; Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; APG7-like; ATG7 autophagy related 7 homolog (S. cerevisiae); ATG7 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 703

• Applicable Applications for ATG7 blocking peptide: Blocking (BL)
• Application Notes: APG7 peptide is used for blocking the activity of APG7 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acids near the amino terminus of human APG7.
• Preparation and Storage: Store APG7 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 5453668
• NCBI GeneID: 10533
• NCBI Accession #: NP_006386
• NCBI GenBank Nucleotide #: NM_006395.2
• UniProt Accession #: O95352; Q7L8L0; Q9BWP2; Q9UFH4; B4E170; E9PB95
• Molecular Weight: 68,618 Da
• NCBI Official Full Name: ubiquitin-like modifier-activating enzyme ATG7 isoform a
• NCBI Official Synonym Full Names: autophagy related 7
• NCBI Official Symbol: ATG7
• NCBI Official Synonym Symbols: GSA7; APG7L; APG7-LIKE
• NCBI Protein Information: ubiquitin-like modifier-activating enzyme ATG7; hAGP7; autophagy-related protein 7; ATG12-activating enzyme E1 ATG7; ATG7 autophagy related 7 homolog; ubiquitin activating enzyme E1-like protein; ubiquitin-activating enzyme E1-like protein
• UniProt Protein Name: Ubiquitin-like modifier-activating enzyme ATG7
• Protein Family: Ubiquitin-like modifier-activating enzyme
• UniProt Gene Name: ATG7
• UniProt Synonym Gene Names: APG7L; APG7-like; hAGP7
• UniProt Entry Name: ATG7_HUMAN

NCBI Description

This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009]

Uniprot Description

ATG7: Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3. Homodimer. Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5. Widely expressed, especially in kidney, liver, lymph nodes and bone marrow. Belongs to the ATG7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Autophagy

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cytoplasm; axoneme; cytosol

Molecular Function: protein binding; protein homodimerization activity; APG8 activating enzyme activity; APG12 activating enzyme activity; ubiquitin activating enzyme activity; transcription factor binding

Biological Process: amino acid metabolic process; central nervous system neuron axonogenesis; positive regulation of apoptosis; regulation of protein ubiquitination; cerebellar Purkinje cell layer development; protein ubiquitination; protein modification process; pyramidal neuron development; C-terminal protein lipidation; liver development; cellular response to starvation; adult walking behavior; neurological system process; post-embryonic development; cellular response to nitrogen starvation; protein transport; cardiac muscle cell development; protein modification by small protein conjugation; mitochondrion degradation; positive regulation of protein catabolic process; positive regulation of protein modification process; protein amino acid lipidation; protein catabolic process; cerebral cortex development; positive regulation of macroautophagy; positive regulation of autophagy; negative regulation of apoptosis