UL16 Binding Protein 4 Recombinant Protein | ULBP4 recombinant protein

Recombinant Human UL16 Binding Protein 4

Cat. Num. AAA140651

• Gene Names: RAET1E; RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7
• Purity: Purity as determined by densitometric image analysis is greater than 85%.
• Synonyms: UL16 Binding Protein 4; Recombinant Human UL16 Binding Protein 4; ULBP4 Human; UL16 Binding Protein 4 Human Recombinant; Retinoic Acid Early Transcript 1E; Lymphocyte Effector Toxicity Activation Ligand; RAE-1-Like Transcript 4; NKG2DL4; N2DL-4; LETAL; ULBP4; RL-4; NKG2D Ligand 4; BA350J20.7; RAET1E2; N2DL4; RAET1E; ULBP4 recombinant protein

• Host: E Coli
• Purity/Purification: Purity as determined by densitometric image analysis is greater than 85%.
• Form/Format: ULBP4 was filtered (0.4 um) and lyophilized in 0.05M Acetate buffer pH 4.0, 1% (w/v) Sucrose and 4% (w/v) Mannitol.; Filtered White lyophilized (freeze-dried) powder.
• Sequence: MKHHHHHHASHSLCFNFTIK SLSRPGQPWC EAQVFLNKNL FLQYNSDNNM VKPLGLLGKK VYATSTWGEL TQTLGEVGRD LRMLLCDIKP QIKTSDPSTL QVEMFCQREA ERCTGASWQF ATNGEKSLLF DAMNMTWTVI NHEASKIKET WKKDRGLEKY FRKLSKGDCD HWLREFLGHW EAMPEPTGRR ST.
• Sequence Length: 227

• Solubility: It is recommended to add 0.1M acetate buffer pH 4.0 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of this antigen is limited. ULBP4 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
• Preparation and Storage: Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Related Product Information for ULBP4 recombinant protein

Introduction: UL16 Binding Protein 4 (ULBP4) is a member of the RAET1 family, which is comprised of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. ULBP4 functions as a ligand for the NKG2D receptor on the surface of NK cells. ULBP4 binding to the receptor induces expansion of anti-tumor cytotoxic lymphocytes. ULBP4 is expressed mainly in the skin, but also in the testis or trachea. ULBP4 is upregulated in different tumors. ULBP4 doesn't interact with the CMV glycoprotein UL16. ULBP4 is also a ligand for the KLRK1 receptor. ULBP4 distributes activating signals to NK cells and stimulates tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.

Description: ULBP4 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (Isoform 3 of Q8TD07) containing 192 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 22kDa.

Product Categories/Family for ULBP4 recombinant protein

Recombinant & Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 343183381
• NCBI GeneID: 135250
• NCBI Accession #: NP_001230254.1
• NCBI GenBank Nucleotide #: NM_001243325.1
• UniProt Accession #: Q8TD07; Q5VYB7; Q5VYB8; Q8TEZ2; Q96L41; A6YF59
• Molecular Weight: 23,978 Da
• NCBI Official Full Name: NKG2D ligand 4 isoform 2
• NCBI Official Synonym Full Names: retinoic acid early transcript 1E
• NCBI Official Symbol: RAET1E
• NCBI Official Synonym Symbols: RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7
• NCBI Protein Information: NKG2D ligand 4
• UniProt Protein Name: NKG2D ligand 4
• UniProt Gene Name: RAET1E
• UniProt Synonym Gene Names: LETAL; N2DL4; ULBP4; N2DL-4; NKG2DL4; RL-4
• UniProt Entry Name: N2DL4_HUMAN

Uniprot Description

RAET1E: Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: plasma membrane

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell mediated cytotoxicity; regulation of immune response; T cell mediated cytotoxicity