Western Blot (WB)
(RAET1E Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RAET1E antibody detected the RAET1E protein (arrow).)
Rabbit anti-Human RAET1E Polyclonal Antibody | anti-RAET1E antibody
RAET1E Antibody (Center)
Western Blot (WB)
(RAET1E Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RAET1E antibody detected the RAET1E protein (arrow).)
Western Blot (WB)
(RAET1E Antibody (Center) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RAET1E antibody detected the RAET1E protein (arrow).)
histocompatibility complex (MHC) class I-related genes located
within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins
contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and
RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g.,
RAET1I, or ULBP1; MIM 605697) in that they have type I
membrane-spanning sequences at their C termini rather than
glycosylphosphatidylinositol anchor sequences. RAET1E is a ligand
for NKG2D (KLRK1; MIM 611817), which is expressed on the surface of
several types of immune cells and is involved in innate and
adaptive immune responses (summary by Radosavljevic et al. (2002)
[PubMed 11827464] and Cao et al. (2007) [PubMed
17470428]).
Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Romphruk, A.V., et al. Immunogenetics 61(9):611-617(2009)
Kong, Y., et al. Blood 114(2):310-317(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Description
RAET1E: Ligand for the NKG2D receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes. Belongs to the MHC class I family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component: integral to membrane; plasma membrane; extracellular region
Molecular Function: peptide antigen binding; natural killer cell lectin-like receptor binding
Biological Process: regulation of immune response; antigen processing and presentation of peptide antigen via MHC class I; natural killer cell mediated cytotoxicity; T cell mediated cytotoxicity
Research Articles on RAET1E
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Product Notes
The RAET1E raet1e (Catalog #AAA9202014) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 150-179. The RAET1E Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RAET1E can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RAET1E raet1e for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAET1E, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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