Uniprot Description
Function: Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes. Ref.2 Ref.5
Subunit structure: Interacts with gK (via N-terminus); this interaction plays a role in the coordinate transport of UL20 and gK to the trans-Golgi network (TGN), and is required for their cell surface expression. Interacts with gB. Ref.6 Ref.8
Subcellular location: Virion. Host cell membrane; Multi-pass membrane protein. Host endosome membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host nucleus membrane; Multi-pass membrane protein. Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN). Ref.3 Ref.4
Sequence similarities: Belongs to the alphaherpesvirinae UL20 family.
Product Notes
The UL20 ul20 (Catalog #
AAA1250563) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-222. The amino acid sequence is listed below: MTMRDDLPLV DRDLVDEAAF GGEEGELPLE EQFSLSSYGT SDFFVSSAYS RLPPHTQPVF SKRVILFLWS FLVLKPLEMV AAGMYYGLTG RVVAPACILA AIVGYYVTWA VRALLLYVNI KRDRLPLSAP VFWGMSVFLG GTALCALFAA AHETFSPDGL FHFIATNQML PPTDPLRTRA LGIACAAGAS MWVAAADSFA ASANFFLARF WTRAILNAPV AF.
It is sometimes possible for the material contained within the vial of
"Protein UL20 (UL20), Recombinant Protein" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
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product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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of any product performance
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