Mouse anti-Human ICOS ligand Monoclonal Antibody | anti-ICOSLG antibody

Anti-ICOS ligand Antibody (PE), Mouse Monoclonal

Cat. Num. AAA8105422

• Gene Names: ICOSLG; B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Protein A
• Synonyms: ICOS ligand; Monoclonal Antibody; Anti-ICOS ligand Antibody (PE); Mouse Monoclonal; ICOS Ligand/B7-H2 Antibody (PE); Mouse MAb; inducible T-cell co-stimulator ligand; Anti-B7-h2 Antibody; Anti-B7H2 Antibody; Anti-B7RP-1 Antibody; Anti-B7RP1 Antibody; Anti-CD275 Antibody; Anti-GL50 Antibody; Anti-ICOS ligand Antibody; Anti-ICOS-L Antibody; Anti-ICOSL Antibody; Anti-ICOSLG Antibody; Anti-LICOS Antibody; anti-ICOSLG antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1
• Clone Number: 01
• Specificity: Human ICOS Ligand/B7-H2
• Purity/Purification: Protein A
• Form/Format: Liquid; Aqueous solution containing 0.5% BSA and 0.09% sodium azide
• Concentration: 5ul/Test, 0.1mg/ml (varies by lot)

• Applicable Applications for anti-ICOSLG antibody: Flow Cytometry (FC/FACS/FCM)
• Immunogen: Recombinant Human ICOS Ligand/B7-H2 protein
• Conjugation: PE
• Preparation: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand/B7-H2 (rh ICOS Ligand/B7-H2) and conjugated with PE under optimum conditions, the unreacted PE was removed.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of ICOSLG(CD275) expression on RPMI8226 cells.)

Related Product Information for anti-ICOSLG antibody

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.

Product Categories/Family for anti-ICOSLG antibody

Cancer Drug Targets

References

Flesch IE. (2002) Inducible costimulator-ligand (ICOS-L). J Biol Regul Homeost Agents. 16(3): 217-9.Kajiwara K, et al. (2009) Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells. Allergol Int. 58(4): 573-83.Wong SC, et al. (2009) Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity. Cell Immunol. 256(1-2): 64-71.

NCBI and Uniprot Product Information

• NCBI GI #: 27477039
• NCBI GeneID: 23308
• NCBI Accession #: NP_056074.1
• NCBI GenBank Nucleotide #: NM_015259.4
• UniProt Accession #: O75144; Q9HD18; Q9NRQ1
• Molecular Weight: 33,349 Da
• NCBI Official Full Name: ICOS ligand
• NCBI Official Synonym Full Names: inducible T-cell co-stimulator ligand
• NCBI Official Symbol: ICOSLG
• NCBI Official Synonym Symbols: B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
• NCBI Protein Information: ICOS ligand; B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; transmembrane protein B7-H2 ICOS ligand
• UniProt Protein Name: ICOS ligand
• Protein Family: ICOS ligand
• UniProt Gene Name: ICOSLG
• UniProt Synonym Gene Names: B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1

Uniprot Description

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function ().