Ubiquitin Carboxyl Terminal Hydrolase L3 (UCHL3) Recombinant Protein | UCHL3 recombinant protein
Recombinant Ubiquitin Carboxyl Terminal Hydrolase L3 (UCHL3)
MGHHHHHHSGSEF-EGQRWLPLEA NPEVTNQFLK QLGLHPNWQF VDVYGMEPEL LSMVPRPVCA VLLLFPITEK YEVFRTEEEE KIKSQGQDVT SSVYFMKQTI SNACGTIGLI HAIANNKDKM HFESGSALKK FLEESVAMSP EERARHLENY DAIRVTHETS AHEGQTEAPS IDEKVDLHFI ALVHVDGHLY ELDGRKPFPI NHGKTSDETL LEDAIEVCKK FMERDPDELR FNAIALSAA
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
NCBI and Uniprot Product Information
NCBI Description
mouse homolog is an enzyme involved in proteolytic processing of polymeric ubiquitin [RGD, Feb 2006]
Uniprot Description
UCHL3: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates. Highly expressed in heart, skeletal muscle, and testis. Inhibited by monoubiquitin and diubiquitin. Belongs to the peptidase C12 family.
Protein type: Ubiquitin conjugating system; EC 3.4.19.12; Protease
Cellular Component: nucleoplasm; cytoplasm; intracellular; nucleus
Molecular Function: peptidase activity; ubiquitin binding; ubiquitin-specific protease activity
Biological Process: ubiquitin-dependent protein catabolic process; cellular response to insulin stimulus; retina development in camera-type eye; eating behavior; positive regulation of fat cell differentiation; protein catabolic process; proteolysis; adult walking behavior
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Product Notes
The UCHL3 uchl3 (Catalog #AAA2012430) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Ubiquitin Carboxyl Terminal Hydrolase L3 (UCHL3) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the UCHL3 uchl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with N-terminal His-Tag, its sequence is listed below. MGHHHHHHSG SEF-EGQRWL PLEA NPEVTNQFLK QLGLHPNWQF VDVYGMEPEL LSMVPRPVCA VLLLFPITEK YEVFRTEEEE KIKSQGQDVT SSVYFMKQTI SNACGTIGLI HAIANNKDKM HFESGSALKK FLEESVAMSP EERARHLENY DAIRVTHETS AHEGQTEAPS IDEKVDLHFI ALVHVDGHLY ELDGRKPFPI NHGKTSDETL LEDAIEVCKK FMERDPDELR FNAIALSAA. It is sometimes possible for the material contained within the vial of "Ubiquitin Carboxyl Terminal Hydrolase L3 (UCHL3), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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