Western Blot (WB)
(SYT8 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SYT8 antibody detected the SYT8 protein (arrow).)
Rabbit anti-Human, mouse SYT8 Polyclonal Antibody | anti-SYT8 antibody
SYT8 Antibody (Center)
Western Blot (WB)
(SYT8 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SYT8 antibody detected the SYT8 protein (arrow).)
Western Blot (WB)
(SYT8 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the SYT8 antibody detected the SYT8 protein (arrow).)
Immunohistochemistry (IHC)
(SYT8 antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human Placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the SYT8 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SYT8 antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human Placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the SYT8 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
structure that includes a transmembrane domain and a cytoplasmic
region composed of 2 C2 domains. Some synaptotagmins are involved
in synaptic membrane fusion, while others have a more general
function in endocytosis. For further information on synaptotagmins,
see MIM 185605.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Li, C., et al. Nature 375(6532):594-599(1995)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Uniprot Description
SYT8: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells. Belongs to the synaptotagmin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: synaptic vesicle; integral to membrane; acrosome; plasma membrane
Molecular Function: transporter activity; calcium-dependent protein binding
Biological Process: acrosome reaction
Research Articles on SYT8
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Product Notes
The SYT8 syt8 (Catalog #AAA9204505) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 60-88. The SYT8 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SYT8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the SYT8 syt8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SYT8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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