Human tripartite motif-containing 27 ELISA Kit | TRIM27 elisa kit
Human Zinc finger protein RFP, TRIM27 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Uniprot Description
TRIM27: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Defects in TRIM27 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 6.3.2.-; Oncoprotein; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 6p22
Cellular Component: nucleoplasm; PML body; nuclear membrane; membrane; retromer complex; integral to plasma membrane; early endosome; cytoplasm; nucleus; endosome
Molecular Function: protein binding; DNA binding; nucleic acid binding; zinc ion binding; metal ion binding; ubiquitin-protein ligase activity; transmembrane receptor protein tyrosine kinase activity; ligase activity
Biological Process: cell proliferation; negative regulation of viral transcription; peptidyl-tyrosine phosphorylation; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; negative regulation of adaptive immune response; innate immune response; negative regulation of protein kinase activity; positive regulation of transcription factor activity; spermatogenesis; negative regulation of tumor necrosis factor production; negative regulation of transcription from RNA polymerase II promoter; retrograde transport, endosome to Golgi
Research Articles on TRIM27
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Product Notes
The Human TRIM27 trim27 (Catalog #AAA9343223) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343223 ELISA Kit recognizes Human TRIM27. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 27, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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