Transferrin R/CD71 Recombinant Protein | CD71 recombinant protein

Recombinant Mouse Transferrin R/CD71 Protein (N-His)

Cat. Num. AAA2557435

• Gene Names: Tfrc; TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Transferrin R/CD71; Recombinant Mouse Transferrin R/CD71 Protein (N-His); Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; CD71; Tfrc; CD71 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Cys89-Phe763
• Sequence Length: 763

• Species: Mouse
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: N-His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CD71 recombinant protein

Protein Construction: Recombinant Mouse Transferrin R is produced by our mammalian expression system and the target gene encoding Cys89-Phe763 is expressed with a 8His tag at the N-terminus.

Background: Transferrin receptor protein 1 (TFRC) belongs to the peptidase M28 family that is synthesized as a 172 amino acid (aa). TFRC regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. It binds one transferrin or HFE molecule per subunit and binds the HLA class II histocompatibility antigen, DR1. It Interacts with SH3BP3 and STEAP3, facilitates TFRC endocytosis in erythroid precursor cells. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. It positively regulates T and B cell proliferation through iron uptake.

NCBI and Uniprot Product Information

• NCBI GI #: 11596855
• NCBI GeneID: 22042
• NCBI Accession #: NP_035768.1
• NCBI GenBank Nucleotide #: NP_035768.1
• UniProt Accession #: Q62351
• Molecular Weight: Molecular Mass: 77kDa; Actual Protein Molecular Mass: 90kDa
• NCBI Official Full Name: transferrin receptor protein 1
• NCBI Official Synonym Full Names: transferrin receptor
• NCBI Official Symbol: Tfrc
• NCBI Official Synonym Symbols: TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik
• NCBI Protein Information: transferrin receptor protein 1
• UniProt Protein Name: Transferrin receptor protein 1
• UniProt Entry Name: TFR1_MOUSE

NCBI Description

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]