SDS-PAGE
Transferrin Receptor / TFRC / CD71 Recombinant Protein | TFRC recombinant protein
Recombinant Mouse Transferrin Receptor / TFRC / CD71 Protein (His tag)
SDS-PAGE
SDS-PAGE
Description: A DNA sequence encoding the extracellular domain of mouse TFRC (Q62351) (Cys 89-Phe 763) was fused with a polyhistidine tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Mice that are deficient in this receptor show impaired erythroid development and abnormal iron homeostasis. [provided by RefSeq, Sep 2015]
Uniprot Description
TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
Protein type: Cell surface; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 16 B3|16 23.06 cM
Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasm; cytoplasmic vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; recycling endosome; recycling endosome membrane
Molecular Function: chaperone binding; double-stranded RNA binding; glycoprotein binding; Hsp70 protein binding; iron ion transmembrane transporter activity; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity
Biological Process: cellular iron ion homeostasis; cellular response to extracellular stimulus; osteoclast differentiation; positive regulation of B cell proliferation; positive regulation of bone resorption; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; transferrin transport
Research Articles on TFRC
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Product Notes
The TFRC tfrc (Catalog #AAA2546807) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant mouse TFRC comprises 694 amino acids and predicts a molecular mass of 78.3 kDa. The apparent molecular mass of mouse TFRC is approximately 80 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the TFRC tfrc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transferrin Receptor / TFRC / CD71, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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