TOR1A recombinant protein

TOR1A, 21-332aa, Human, His tag, E Coli (Denatured)

Cat. Num. AAA205414

• Gene Names: TOR1A; DQ2; DYT1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: TOR1A; 21-332aa; Human; His tag; E Coli (Denatured); Torsin-1A; DQ2; DYT1; TOR1A recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MVEPISLGLA LAGVLTGYIY PRLYCLFAEC CGQKRSLSRE ALQKDLDDNL FGQHLAKKII LNAVFGFINN PKPKKPLTLS LHGWTGTGKN FVSKIIAENI YEGGLNSDYV HLFVATLHFP HASNITLYKD QLQLWIRGNV SACARSIFIF DEMDKMHAGL IDAIKPFLDY YDLVDGVSYQ KAMFIFLSNA GAERITDVAL DFWRSGKQRE DIKLKDIEHA LSVSVFNNKN SGFWHSSLIH RNLIDYFVPF LPLEYKHLKM CIRVEMQSRG YEIDEDIVSR VAEEMTFFPK EERVFSDKGC KTVFTKLDYY YDD
• Sequence Length: 332

• Applicable Applications for TOR1A recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for TOR1A recombinant protein

TOR1A is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. Recombinant human TOR1A protein, His-tag at N-terminus, was expressed in E Coli.

Product Categories/Family for TOR1A recombinant protein

Neuroscience

References

Schmidt A, et al. (2012). Parkinsonism Relat Disord. 2012 Jun;18 (5):690-1.

NCBI and Uniprot Product Information

• NCBI GI #: 12653777
• NCBI GeneID: 1861
• Molecular Weight: 38 kDa (333aa)
• NCBI Official Full Name: Torsin family 1, member A (torsin A)
• NCBI Official Synonym Full Names: torsin family 1 member A
• NCBI Official Symbol: TOR1A
• NCBI Official Synonym Symbols: DQ2; DYT1
• NCBI Protein Information: torsin-1A
• UniProt Protein Name: Torsin-1A
• Protein Family: Torsin
• UniProt Gene Name: TOR1A
• UniProt Synonym Gene Names: DQ2; DYT1; TA; TORA

NCBI Description

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]

Uniprot Description

Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.