Rabbit anti-Human TOR1A Polyclonal Antibody | anti-TOR1A antibody

TOR1A, CT (TOR1A, DQ2, DYT1, Torsin-1A, Dystonia 1 protein, Torsin family 1 member A) (Biotin)

Cat. Num. AAA6357408

• Gene Names: TOR1A; DQ2; DYT1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TOR1A; Polyclonal Antibody; CT (TOR1A; DQ2; DYT1; Torsin-1A; Dystonia 1 protein; Torsin family 1 member A) (Biotin); Torsin family 1 member A; anti-TOR1A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-TOR1A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TOR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the C-terminal region of human TOR1A.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TOR1A Antibody (C-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the TOR1A antibody detected the TOR1A protein (arrow).)

Related Product Information for anti-TOR1A antibody

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq].

Product Categories/Family for anti-TOR1A antibody

Antibodies; Proteins

References

Sharma, N., et al. Mov. Disord. 25(13):2183-2187(2010). Kaiser, F.J., et al. Ann. Neurol. 68(4):554-559(2010). Gavarini, S., et al. Ann. Neurol. 68(4):549-553(2010). Granata, A., et al. Eur. J. Neurol. 17 SUPPL 1, 81-87 (2010): Warner, T.T., et al. Biochem. Soc. Trans. 38(2):452-456(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 4557541
• NCBI GeneID: 1861
• NCBI Accession #: NP_000104.1
• NCBI GenBank Nucleotide #: NM_000113.2
• UniProt Accession #: O14656; Q53Y64; Q96CA0; B2RB58
• Molecular Weight: 332
• NCBI Official Full Name: torsin-1A
• NCBI Official Synonym Full Names: torsin family 1, member A (torsin A)
• NCBI Official Symbol: TOR1A
• NCBI Official Synonym Symbols: DQ2; DYT1
• NCBI Protein Information: torsin-1A; dystonia 1 protein; torsin family 1 member A; dystonia 1, torsion (autosomal dominant; torsin A)
• UniProt Protein Name: Torsin-1A
• Protein Family: Torsin
• UniProt Gene Name: TOR1A
• UniProt Synonym Gene Names: DQ2; DYT1; TA; TORA
• UniProt Entry Name: TOR1A_HUMAN

Uniprot Description

TOR1A: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: synaptic vesicle; nuclear membrane; transport vesicle; cytoskeleton; growth cone; cytoplasmic vesicle membrane; membrane; intracellular membrane-bound organelle; endoplasmic reticulum lumen; nuclear envelope; cell junction; secretory granule

Molecular Function: protein binding; kinesin binding; cytoskeletal protein binding; ATPase activity; unfolded protein binding; misfolded protein binding; ATP binding

Biological Process: protein deneddylation; chaperone cofactor-dependent protein folding; organelle organization and biogenesis; synaptic vesicle transport; regulation of dopamine uptake; intermediate filament cytoskeleton organization and biogenesis; response to oxidative stress; cell adhesion; neurite development; nuclear membrane organization and biogenesis; protein homooligomerization

Disease: Dystonia 1, Torsion, Autosomal Dominant