SDS-Page
(Recombinant Mouse TNFRSF4/OX40 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
TNFRSF4/OX40 Recombinant Protein | TNFRSF4 recombinant protein
Recombinant Mouse TNFRSF4/OX40 Protein
Gene Names
Tnfrsf4; Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
Purity
>95% by SDS-PAGE.
Synonyms
TNFRSF4/OX40; Recombinant Mouse TNFRSF4/OX40 Protein; Tumor necrosis factor receptor superfamily member 4; Tnfrsf4; OX40; CD134; Txgp1; TNFRSF4 recombinant protein
Host
Human Cells
Purity/Purification
>95% by SDS-PAGE.
Form/Format
Lyophilized from a 0.2 uM filtered solution of PBS, pH 7.4
Sequence
VTARRLNCVKHTYPSGHKCCRECQPGHGMVSRCDHTRDTLCHPCETGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTQDTVCRCRPGTQPRQDSGYKLGVDCVPCPPGHFSPGNNQACKPWTNCTLSGKQTRHPASDSLDAVCEDRSLLATLLWETQRPTFRPTTVQSTTVWPRTSELPSPPTLVTPEGP
Sequence Length
272
Species
Mouse
Endotoxin
< 1 EU/ug of the protein by LAL method.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in 1X PBS.
Tag
Fc tag at the C-terminus
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Mouse TNFRSF4/OX40 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
SDS-Page
(Recombinant Mouse TNFRSF4/OX40 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
Related Product Information for TNFRSF4 recombinant protein
Description: Recombinant Mouse TNFRSF4/OX40 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Val20-Pro211) of mouse TNFRSF4/OX40 (Accession #P47741) fused with an Fc tag at the C-terminus.
Background: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamilywhich plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed onCD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation byCD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur whenactivated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokineproduction, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals arecritical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interactionregulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
Background: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamilywhich plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed onCD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation byCD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur whenactivated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokineproduction, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals arecritical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interactionregulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
Product Categories/Family for TNFRSF4 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Tumor necrosis factor receptor superfamily member 4
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 4
NCBI Official Symbol
Tnfrsf4
NCBI Official Synonym Symbols
Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
Protein Family
UniProt Gene Name
Tnfrsf4
UniProt Synonym Gene Names
Ox40; Txgp1
UniProt Entry Name
TNR4_MOUSE
Uniprot Description
TNFRSF4: Receptor for TNFSF4/OX40L/GP34.
Protein type: Apoptosis; Receptor, misc.; Membrane protein, integral
Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: protein binding; tumor necrosis factor receptor activity
Biological Process: regulation of apoptosis; T cell proliferation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; programmed cell death; positive regulation of B cell proliferation; cellular defense response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; regulation of protein kinase activity; inflammatory response
Research Articles on TNFRSF4
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Product Notes
The TNFRSF4 tnfrsf4 (Catalog #AAA9140107) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: VTARRLNCVK HTYPSGHKCC RECQPGHGMV SRCDHTRDTL CHPCETGFYN EAVNYDTCKQ CTQCNHRSGS ELKQNCTPTQ DTVCRCRPGT QPRQDSGYKL GVDCVPCPPG HFSPGNNQAC KPWTNCTLSG KQTRHPASDS LDAVCEDRSL LATLLWETQR PTFRPTTVQS TTVWPRTSEL PSPPTLVTPE GP. It is sometimes possible for the material contained within the vial of "TNFRSF4/OX40, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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