OX40L Receptor Active Protein | TNFRSF4 active protein

Recombinant Human OX40L Receptor Protein

Cat. Num. AAA2556713

• Gene Names: TNFRSF4; OX40; ACT35; CD134; IMD16; TXGP1L
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: OX40L Receptor; Recombinant Human OX40L Receptor Protein; Tumor Necrosis Factor Receptor Superfamily Member 4; TNFRSF4; OX40; CD134; Txgp1; TNFRSF4 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Length: 277

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Leu29-Ala216
• Fusion Tag: C-6His
• Activity: Measured by its binding ability in a functional ELISA. 2. Immobilized human TNFRSF4-his at 2 mug/mL (100 mul/well) can bind human TNFSF4/mFc, The EC50 of human TNFSF4/mFc is 29 ng/mL.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for TNFRSF4 active protein

Protein Construction: Recombinant Human OX40L Receptor is produced by our Mammalian expression system and the target gene encoding Leu29-Ala216 is expressed with a 6His tag at the C-terminus.

Background: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

NCBI and Uniprot Product Information

• NCBI GI #: 4507579
• NCBI GeneID: 7293
• NCBI Accession #: NP_003318.1
• NCBI GenBank Nucleotide #: NM_003327.4
• UniProt Accession #: P43489; Q13663; Q2M312; Q5T7M0
• Molecular Weight: Molecular Mass: 21.0kDa; Actual Protein Molecular Mass: 35-40kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 4
• NCBI Official Synonym Full Names: TNF receptor superfamily member 4
• NCBI Official Symbol: TNFRSF4
• NCBI Official Synonym Symbols: OX40; ACT35; CD134; IMD16; TXGP1L
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 4
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 4
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF4
• UniProt Synonym Gene Names: TXGP1L

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.