NCBI Description
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Description
TIPARP: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.
Protein type: Transferase; EC 2.4.2.30
Chromosomal Location of Human Ortholog: 3q25.31
Cellular Component: nucleus
Molecular Function: metal ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: estrogen metabolic process; androgen metabolic process; platelet-derived growth factor receptor signaling pathway; palate development; multicellular organismal metabolic process; post-embryonic development; smooth muscle development; protein amino acid ADP-ribosylation; nitrogen compound metabolic process; skeletal morphogenesis; positive regulation of protein catabolic process; hemopoiesis; vasculogenesis; kidney development; female gonad development
Product Notes
The Human TIPARP tiparp (Catalog #
AAA9337014) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337014 ELISA Kit recognizes Human TIPARP.
It is sometimes possible for the material contained within the vial of
"TCDD-inducible poly (ADP-ribose) polymerase, ELISA Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
details on this or any of our
other policies, please see our
Terms & Conditions page.
