Human TCDD-inducible poly (ADP-ribose) polymerase ELISA Kit | TIPARP elisa kit
Human TCDD-inducible poly [ADP-ribose] polymerase, TIPARP ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Description
TIPARP: Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.
Protein type: Transferase; EC 2.4.2.30
Chromosomal Location of Human Ortholog: 3q25.31
Cellular Component: nucleus
Molecular Function: metal ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: estrogen metabolic process; androgen metabolic process; platelet-derived growth factor receptor signaling pathway; palate development; multicellular organismal metabolic process; post-embryonic development; smooth muscle development; protein amino acid ADP-ribosylation; nitrogen compound metabolic process; skeletal morphogenesis; positive regulation of protein catabolic process; hemopoiesis; vasculogenesis; kidney development; female gonad development