Rabbit anti-Human PDE1A Polyclonal Antibody | anti-PDE1A antibody

PDE1A (Calcium/Calmodulin-dependent 3',5'-cyclic Nucleotide Phosphodiesterase 1A, Cam-PDE 1A, 61kD Cam-PDE, hCam-1, MGC26303) APC

Cat. Num. AAA6388768

• Gene Names: PDE1A; HCAM1; HCAM-1; HSPDE1A; CAM-PDE-1A
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PDE1A; Polyclonal Antibody; PDE1A (Calcium/Calmodulin-dependent 3'; 5'-cyclic Nucleotide Phosphodiesterase 1A; Cam-PDE 1A; 61kD Cam-PDE; hCam-1; MGC26303) APC; anti-PDE1A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PDE1A.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-PDE1A antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human PDE1A, aa1-545 (NP_005010.2).
• Immunogen Sequence: MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKHDETHS
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PDE1A expression in transfected 293T cell line by PDE1A polyclonal antibody. Lane 1: PDE1A transfected lysate (62.3kD). Lane 2: Non-transfected lysate)

Related Product Information for anti-PDE1A antibody

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

Product Categories/Family for anti-PDE1A antibody

Antibodies; Enzymes; Phosphodiesterase

NCBI and Uniprot Product Information

• NCBI GI #: 21361262
• NCBI GeneID: 5136
• NCBI Accession #: NP_005010.2
• NCBI GenBank Nucleotide #: NM_005019.3
• Molecular Weight: 59,271 Da
• NCBI Official Full Name: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1
• NCBI Official Synonym Full Names: phosphodiesterase 1A
• NCBI Official Symbol: PDE1A
• NCBI Official Synonym Symbols: HCAM1; HCAM-1; HSPDE1A; CAM-PDE-1A
• NCBI Protein Information: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
• Protein Family: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase

NCBI Description

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]