Human transcription elongation factor B (SIII) , polypeptide 2 (18kDa, elongin B) ELISA Kit | TCEB2 elisa kit
Human Transcription elongation factor B polypeptide 2, TCEB2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
Uniprot Description
TCEB2: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
Chromosomal Location of Human Ortholog: 16p12.3
Cellular Component: nucleoplasm; Cul2-RING ubiquitin ligase complex; Cul5-RING ubiquitin ligase complex; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; protein ubiquitination; protein complex assembly; gene expression
Research Articles on TCEB2
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Product Notes
The Human TCEB2 tceb2 (Catalog #AAA9328077) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328077 ELISA Kit recognizes Human TCEB2. It is sometimes possible for the material contained within the vial of "transcription elongation factor B (SIII) , polypeptide 2 (18kDa, elongin B), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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