Chemical Structure
(Chemical structure of DMPO (SIH-324), a Nitrone adduct formation. CAS #: 3317-61-1. Molecular Formula: C6H11NO. Molecular Weight: 13.16 g/mol.)
DMPO small molecule
DMPO
Purity
>98%
Synonyms
DMPO; Spin trapping reagent; DMPO small molecule
Host
Synthetic
Purity/Purification
>98%
Form/Format
Colorless Solid
Sequence Length
119
Solubility
Soluble to 100 mM in ethanol and to 100 mM in DMSO
CAS Number
3317-61-1
Molecular Formula
C6H11NO
SMILES
CC1(CCC=[N+]1[O-])C
InChI
1S/C6H11NO/c1-6(2)4-3-5-7(6)8/h5H,3-4H2,1-2H3
InChI Key
VCUVETGKTILCLC-UHFFFAOYSA-N
PubChem CID
1774
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of DMPO (SIH-324), a Nitrone adduct formation. CAS #: 3317-61-1. Molecular Formula: C6H11NO. Molecular Weight: 13.16 g/mol.)
Chemical Structure
(Chemical structure of DMPO (SIH-324), a Nitrone adduct formation. CAS #: 3317-61-1. Molecular Formula: C6H11NO. Molecular Weight: 13.16 g/mol.)
Related Product Information for DMPO small molecule
The formation of free radicals and other highly reactive oxygen species has been implicated in the pathogenesis of many disease states (1). The ability to identify these species is crucial, and spin trapping has accomplished this goal. DMPO (5,5-dimethyl-1-pyrroline N-oxide) is one of the least toxic to cells and animals, and possesses convenient pharmacokinetics (uptake, distribution, metabolism and excretion) in biological systems (2-6). Recent studies have determined that nitric oxide may substantially affect the quantitative determination of DMPO adducts, and therefore extra caution is required when studying generation of these species in the presence of nitric oxide or its radicals (1). DMPO adducts can be generated with protein and DNA radicals (7).
Product Categories/Family for DMPO small molecule
References
1. Reszka K.J., et al. (2006) Nitric Oxide 15: 133-141. 2. Ramirez D.C., Gomez-Mejiba S.E., and Mason R.P. (2007) Nat Protoc. 2(3): 512-522. 3. Khan N., et al. (2003) Free Radic. Biol. Med 34:1473-1481. 4. Haseloff R.F., et al. (1997) FEBS Lett 418:73-75. 5. Schaefer C.F., Janzen E.G., West M.S., Poyer J.L., and Kosanke S.D. (1996) Free Radic. Biol. Med 21:427-436. 6. Anzai K., et al. (2003) Arch. Biochem. Biophys 415:251-256. 7. Chatterjee S., Ehrenshaft, M., Bhattacharjee,S., Derterding, L.J., Bonini, M.G., Corbett, J., Kadiiska, M.B., Tomer K.B. and Mason, R.P. 2009 Free Radic. Med. and Biol. 46:454-461.
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
13.16
NCBI Official Full Name
DmpO
UniProt Protein Name
DmpO
Protein Family
UniProt Gene Name
dmpO
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Product Notes
The DMPO dmpo (Catalog #AAA808029) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DMPO, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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