PKA C alpha/beta/gamma Blocking Peptide | PRKACA blocking peptide
PKA C alpha/beta/gamma (pT198) Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
Uniprot Description
PKACA: catalytic subunit of cAMP-dependent protein kinase alpha, an AGC kinase. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Two splice-variant isoforms have been described.
Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.11; Protein kinase, Ser/Thr (non-receptor); AGC group; PKA family
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: AMP-activated protein kinase complex; cAMP-dependent protein kinase complex; centrosome; cytosol; membrane; mitochondrion; nucleoplasm; nucleus
Molecular Function: ATP binding; cAMP-dependent protein kinase activity; protein binding; protein kinase binding; protein serine/threonine/tyrosine kinase activity; ubiquitin protein ligase binding
Biological Process: activation of protein kinase A; blood coagulation; carbohydrate metabolic process; cytosolic calcium ion homeostasis; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G2/M transition of mitotic cell cycle; gluconeogenesis; glucose metabolic process; innate immune response; mitotic cell cycle; nerve growth factor receptor signaling pathway; organelle organization and biogenesis; peptidyl-serine phosphorylation; phospholipase C activation; protein amino acid phosphorylation; regulation of heart rate; regulation of insulin secretion; regulation of osteoblast differentiation; regulation of protein binding; renal water homeostasis; signal transduction; sperm capacitation; stimulatory C-type lectin receptor signaling pathway; transmembrane transport; triacylglycerol catabolic process; water transport
Research Articles on PRKACA
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Product Notes
The PRKACA prkaca (Catalog #AAA8244090) is a Blocking Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The PKA C alpha/beta/gamma (pT198) Blocking Peptide reacts with Human, Mouse, Rat, Bovine, Dog, Pig, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's PKA C alpha/beta/gamma can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours. Researchers should empirically determine the suitability of the PRKACA prkaca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PKA C alpha/beta/gamma, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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