ULBP3 sirna
ULBP3 siRNA (Human)
Gene Names
ULBP3; RAET1N
Reactivity
Human
Applications
RNA Interference (RNAi)
Purity
> 97%
Synonyms
ULBP3; ULBP3 siRNA (Human); N2DL3; RAET1N; NKG2D ligand 3; N2DL-3; NKG2DL3; ALCAN-gamma; Retinoic acid early transcript 1N; ULBP3 sirna
Host
Synthetic
Reactivity
Human
Specificity
ULBP3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Sequence Length
244
Applicable Applications for ULBP3 sirna
RNA Interference (RNAi)
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ULBP3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Related Product Information for ULBP3 sirna
siRNA to inhibit ULBP3 expression using RNA interference
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,949 Da
NCBI Official Full Name
NKG2D ligand 3
NCBI Official Synonym Full Names
UL16 binding protein 3
NCBI Official Symbol
ULBP3
NCBI Official Synonym Symbols
RAET1N
NCBI Protein Information
NKG2D ligand 3
UniProt Protein Name
NKG2D ligand 3
Protein Family
UniProt Gene Name
ULBP3
UniProt Synonym Gene Names
N2DL3; RAET1N; N2DL-3; NKG2DL3
UniProt Entry Name
N2DL3_HUMAN
Uniprot Description
ULBP3: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. Belongs to the MHC class I family.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 6q25
Cellular Component: anchored to plasma membrane; plasma membrane
Molecular Function: peptide antigen binding; natural killer cell lectin-like receptor binding
Biological Process: antigen processing and presentation of peptide antigen via MHC class I; regulation of immune response; viral reproduction; natural killer cell mediated cytotoxicity; natural killer cell activation
Research Articles on ULBP3
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Product Notes
The ULBP3 ulbp3 (Catalog #AAA8240152) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The ULBP3 siRNA (Human) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ULBP3 can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the ULBP3 ulbp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ULBP3, siRNA" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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