SDS-PAGE
STK16 / PKL12 / MPSK recombinant protein
Recombinant Human STK16 / PKL12 / MPSK Protein (His & NusA tag)
Gene Names
STK16; PSK; KRCT; MPSK; TSF1; hPSK; PKL12
Purity
> 85 % as determined by SDS-PAGE
Synonyms
STK16 / PKL12 / MPSK; Recombinant Human STK16 / PKL12 / MPSK Protein (His & NusA tag); FLJ39635; KRCT; MGC16211; MPSK; PKL12; TSF1; STK16 / PKL12 / MPSK recombinant protein
Host
E Coli
Purity/Purification
> 85 % as determined by SDS-PAGE
Form/Format
Supplied as sterile PBS, pH 7.4
Sequence Length
305
Application Notes
The recombinant human STK16/NusA chimera consisting of 820 amino acids and has a calculated molecular mass of 92 kDa. It migrates as an 105 kDa band in SDS-PAGE under reducing conditions.
Predicted N Terminal
Met
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for STK16 / PKL12 / MPSK recombinant protein
Background: Serine/threonine-protein kinase 16, also known as myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein which is ubiquitously expressed at very low levels. STK16 / MPSK1 belongs to the protein kinase superfamily and Ser/Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Some factors such as Smads (Sma and Mad proteins) and TGF-beta activating kinase 1 have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. STK16 / MPSK1 is an unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. STK16 / MPSK1 is a protein kinase that act on both serine and threonine residues. STK16 / MPSK1 possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. STK16 / MPSK1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. STK16 / MPSK1 mRNA as well as its protein level were stimulated by TGF-beta treatment.
Description: A DNA sequence encoding the native human STK16 (AAH02618.1) (Met 1-Ile 305) was fused with the polyhistidine-tagged NusA tag at the N-terminus.
Description: A DNA sequence encoding the native human STK16 (AAH02618.1) (Met 1-Ile 305) was fused with the polyhistidine-tagged NusA tag at the N-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
34,656 Da
NCBI Official Full Name
Serine/threonine kinase 16
NCBI Official Synonym Full Names
serine/threonine kinase 16
NCBI Official Symbol
STK16
NCBI Official Synonym Symbols
PSK; KRCT; MPSK; TSF1; hPSK; PKL12
NCBI Protein Information
serine/threonine-protein kinase 16
UniProt Protein Name
Serine/threonine-protein kinase 16
UniProt Gene Name
STK16
UniProt Synonym Gene Names
MPSK1; PKL12; TSF1; MPSK; TSF-1
Uniprot Description
MPSK1: a protein kinase of the STE20 family. Activated by caspase-mediated cleavage
Protein type: EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; NAK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cytoplasm
Molecular Function: protein binding; protein serine/threonine kinase activity
Biological Process: protein amino acid autophosphorylation
Research Articles on STK16 / PKL12 / MPSK
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Product Notes
The STK16 / PKL12 / MPSK stk16 (Catalog #AAA2545041) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The recombinant human STK16/NusA chimera consisting of 820 amino acids and has a calculated molecular mass of 92 kDa. It migrates as an 105 kDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the STK16 / PKL12 / MPSK stk16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "STK16 / PKL12 / MPSK, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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