SDS-PAGE
SLAMF6 / Ly108 recombinant protein
Recombinant Human SLAMF6 / Ly108 Protein
SDS-PAGE
SDS-PAGE
Description: A DNA sequence encoding the human SLAMF6 (Q96DU3-1) (Met1-Met226) was expressed with six amino acids (LEVLFQ) at the C-terminus.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Uniprot Description
SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23.2-q23.3
Cellular Component: plasma membrane
Molecular Function: protein binding
Biological Process: positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; regulation of immune response
Research Articles on SLAMF6 / Ly108
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Product Notes
The SLAMF6 / Ly108 slamf6 (Catalog #AAA2545626) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant human SLAMF6 consists of 212 amino acids and predicts a molecular mass of 23.9 KDa. It migrates as an approximately 37-43 KDa band in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the SLAMF6 / Ly108 slamf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLAMF6 / Ly108, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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