Phosphoinositide 3-kinase beta P110beta/p85a Active Protein | PI3Kb active protein
Recombinant Human Phosphoinositide 3-kinase beta P110beta/p85a
Purity
Greater than 90.0% as determined by SDS Page.
Synonyms
Phosphoinositide 3-kinase beta P110beta/p85a; Recombinant Human Phosphoinositide 3-kinase beta P110beta/p85a; PI3Kb Human; Phosphoinositide 3-kinase beta p110beta/p85alpha Human Recombinant; PI3Kb; PI3Kb active protein
Host
Sf9 Insect Cells
Purity/Purification
Greater than 90.0% as determined by SDS Page.
Form/Format
0.9 mg/ml solution in PBS and 2mM MgCl2.
Sterile filtered liquid formualtion.
Sterile filtered liquid formualtion.
Biological Activity
The specific activity was found to be 3,000 units/mg (1 unit is defined as 1 picomole phosphate transferred to PIP2 per minute).
Preparation and Storage
PI3Kb although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Related Product Information for PI3Kb active protein
Introduction: The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation ofPI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin receptor substrate (IRS) proteins (e.g. IRS-1 and IRS-2). It was also shown that PI3Kb is involved in apoptosis in human colon carcinoma cells. Injection of neutralizing antibodies specific to p110b in WiDr,HCT116 and CO 115 adenocarcinoma cells inhibited de novo DNA synthesis.PI3Kb is the major PI3K isoform required for apoptotic cell and Fc-g receptor mediated phagocytosis shown for primary mouse macrophages and the Jurkat human leukemia T cell line.It was shown by several research groups that the catalytic subunit of PI3Kb can be activated by Gbg subunits of G-protein coupled receptors.
Product Categories/Family for PI3Kb active protein
Similar Products
Product Notes
The PI3Kb (Catalog #AAA142827) is an Active Protein produced from Sf9 Insect Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Phosphoinositide 3-kinase beta P110beta/p85a, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
