Serpin D1/Heparin Cofactor II/HCF2 Recombinant Protein | HCF2 recombinant protein
Recombinant Mouse Serpin D1/Heparin Cofactor II/HCF2 Protein (C-6His)
Gene Names
Serpind1; HCII; Hcf2; HC-II; AA985900; AI303446
Purity
>95% as determined by reducing SDS-PAGE.
Synonyms
Serpin D1/Heparin Cofactor II/HCF2; Recombinant Mouse Serpin D1/Heparin Cofactor II/HCF2 Protein (C-6His); Heparin cofactor 2; Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; Serpin D1; HCF2 recombinant protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 mum filtered solution of 20mM HEPES, 150mM NaCl, pH 7.4.
Sequence Positions
Glu24-Ser478
Sequence Length
478
Species
Mouse
Endotoxin
<1.0 EU per mug as determined by LAL test.
Fusion Tag
C-6His
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Related Product Information for HCF2 recombinant protein
SerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Mass: 53.1 kDa
Actual Protein Molecular Mass: 70-90 kDa
Actual Protein Molecular Mass: 70-90 kDa
NCBI Official Full Name
heparin cofactor 2
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade D, member 1
NCBI Official Symbol
Serpind1
NCBI Official Synonym Symbols
HCII; Hcf2; HC-II; AA985900; AI303446
NCBI Protein Information
heparin cofactor 2
UniProt Protein Name
Heparin cofactor 2
UniProt Gene Name
Serpind1
UniProt Synonym Gene Names
Hcf2; Hcii; HC-II
Uniprot Description
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Research Articles on HCF2
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Product Notes
The HCF2 serpind1 (Catalog #AAA2553608) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Glu24-Ser478. It is sometimes possible for the material contained within the vial of "Serpin D1/Heparin Cofactor II/HCF2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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