Immunohistochemistry (IHC)
(Immunochemical staining of mouse SERPIND1 in mouse liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.)
Rabbit anti-Mouse SerpinD1 Polyclonal Antibody | anti-SerpinD1 antibody
Anti-SerpinD1 Antibody, Rabbit Polyclonal
Gene Names
Serpind1; HCII; Hcf2; AA985900; AI303446
Reactivity
Mouse
Applications
ELISA, Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
SerpinD1; Polyclonal Antibody; Anti-SerpinD1 Antibody; Rabbit Polyclonal; SerpinD1/HCII Antibody; Rabbit PAb; Antigen Affinity Purified; serpin peptidase inhibitor; clade D (heparin cofactor); member 1; Anti-AA985900 Antibody; Anti-AI30344 6 Antibody; Anti-AI303446 Antibody; Anti-Hcf2 Antibody; Anti-HCII Antibody; Anti-MGC107662 Antibody; Anti-Serpind1 Antibody; anti-SerpinD1 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Mouse SerpinD1/HCII
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-SerpinD1 antibody
ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
ELISA: 1:1000-1:2000
IHC-P: 1:500-1:2000
IHC-P: 1:500-1:2000
Immunogen
Recombinant Mouse SerpinD1 protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Mouse SerpinD1 (rM SerpinD1). SerpinD1 specific IgG was purified by mouse SerpinD1 affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of mouse SERPIND1 in mouse liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.)
Immunohistochemistry (IHC)
(Immunochemical staining of mouse SERPIND1 in mouse liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to hepatocyte.)
Related Product Information for anti-SerpinD1 antibody
SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
References
Rau JC, et al. (2009) Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Exp Mol Pathol. 87(3): 178-83.Aihara K, et al. (2009) Heparin cofactor II as a novel vascular protective factor against atherosclerosis. J Atheroscler Thromb. 16(5): 523-31.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
54,497 Da
NCBI Official Full Name
heparin cofactor 2
NCBI Official Synonym Full Names
serine (or cysteine) peptidase inhibitor, clade D, member 1
NCBI Official Symbol
Serpind1
NCBI Official Synonym Symbols
HCII; Hcf2; AA985900; AI303446
NCBI Protein Information
heparin cofactor 2; HC-II; serpin D1; heparin cofactor II; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
UniProt Protein Name
Heparin cofactor 2
Protein Family
UniProt Gene Name
Serpind1
UniProt Synonym Gene Names
Hcf2; Hcii; HC-II
UniProt Entry Name
HEP2_MOUSE
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Product Notes
The SerpinD1 serpind1 (Catalog #AAA8111019) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-SerpinD1 Antibody, Rabbit Polyclonal reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SerpinD1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P). ELISA: 1:1000-1:2000 IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the SerpinD1 serpind1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SerpinD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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