Protein transport protein Sec24B (SEC24B) Recombinant Protein | SEC24B recombinant protein

Recombinant Human Protein transport protein Sec24B (SEC24B) , partial

• Gene Names: SEC24B; SEC24
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein transport protein Sec24B (SEC24B); Recombinant Human Protein transport protein Sec24B (SEC24B); partial; SEC24B recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1233

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for SEC24B recombinant protein

This protein is a member of the SEC24 subfamily of the SEC23
SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 112382214
• NCBI GeneID: 10427
• NCBI Accession #: NP_001036199.1
• NCBI GenBank Nucleotide #: NM_001042734.3
• UniProt Accession #: O95487; Q0VG08; B7ZKM8; B7ZKN4
• Molecular Weight: 140,421 Da
• NCBI Official Full Name: protein transport protein Sec24B isoform b
• NCBI Official Synonym Full Names: SEC24 homolog B, COPII coat complex component
• NCBI Official Symbol: SEC24B
• NCBI Official Synonym Symbols: SEC24
• NCBI Protein Information: protein transport protein Sec24B
• UniProt Protein Name: Protein transport protein Sec24B
• Protein Family: Protein transport protein
• UniProt Gene Name: SEC24B

NCBI Description

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Description

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).