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38 results for "FGFR1 2 3 inhibitor" - showing 1-38
Immunohistochemistry (IHC)
(At 1/100 staining Human colorectal cancer by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4 degree C overnight. An HRP conjugated anti-Mouse antibody was used as the secondary antibody.)
p38 MAPK, Monoclonal Antibody (Cat# AAA9629034)
Full Name
p38 MAPK Monoclonal Antibody
Gene Names
MAPK14; RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
Purity
Affinity-chromatography.
Pricing
$280/0.1 mL | $325/0.2 mL | $1,305/5x0.2 mL
Testing Data
(Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRalpha, mutant FLT3 phosphorylation and LYN. It potently inhibited other clinically important ABL kinase domain mutants with IC50 from 0.30 to 0.44 nM and inhibited SRC with an IC50 of 5.4 nM. It inhibits the proliferation of mutant FLT3-positive cells with an IC50 of 13 nM and that inhibits mutant FLT3 phosphorylation with an IC50 of 1 nM and the proliferation of BCR-ABL1 T315I-positive Ba/F3 cells with an IC50 of 8 nM. It inhibited all tested BCR-ABL mutants with low nM IC50s in cellular and biochemical assays, suppressed BCR-ABL(T315I)-driven tumor growth in mice, and completely abrogated resistance in cell-based mutagenesis screens. AP24534 is used for treatment of CML. It did not inhibit Aurora kinase family members, nor did it inhibit insulin receptor or cyclin-dependent kinase 2 (CDK2)/Cyclin E (IC50 > 1000-fold relative to native ABL. [1][2][3])
Ponatinib, Inhibitor (Cat# AAA8506540)
Full Name
Ponatinib (AP24534)
Pricing
$440/10 mg | $1,940/5x10 mg
FIIN-3, Inhibitor (Cat# AAA579596)
Full Name
FIIN-3
Purity
97.6%
Pricing
$230/1 mg | $265/2 mg | $350/5 mg | $480/10 mg | $830/25 mg | $1,245/50 mg | $1,855/100 mg | $475/1 mL (in DMSO) | $8,070/5x100 mg
S49076, Inhibitor (Cat# AAA578326)
Full Name
S49076
Purity
98.0%
Pricing
$210/2 mg | $240/5 mg | $265/10 mg | $375/25 mg | $545/50 mg | $905/100 mg | $240/1 mL (in DMSO) | $3,810/5x100 mg
Erdafitinib, Inhibitor (Cat# AAA579723)
Full Name
Erdafitinib
Purity
99.04%
Pricing
$180/2 mg | $195/5 mg | $215/10 mg | $265/25 mg | $290/50 mg | $360/100 mg | $200/1 mL (in DMSO) | $1,350/5x100 mg
S49076, Inhibitor (Cat# AAA579641)
Full Name
S49076 HCl
Purity
98.0%
Pricing
$200/1 mg | $230/2 mg | $255/5 mg | $320/10 mg | $425/25 mg | $605/50 mg | $980/100 mg | $4,130/5x100 mg
JK-P3, Inhibitor (Cat# AAA5750114)
Full Name
JK-P3
Purity
99.5%
Pricing
$195/2 mg | $225/5 mg | $275/10 mg | $430/25 mg | $675/50 mg | $225/1 mL (in DMSO) | $2,770/5x50 mg
Structure
Amlexanox, Inhibitor (Cat# AAA3605609)
Full Name
Amlexanox
Purity
>98% (HPLC)
Pricing
$185/5 mg | $190/10 mg | $200/25 mg | $215/50 mg | $230/100 mg | $760/5x100 mg
Structure
FIIN-3, Inhibitor (Cat# AAA3607347)
Full Name
FIIN-3
Purity
>98% (HPLC)
Pricing
$250/2 mg | $335/5 mg | $445/10 mg | $755/25 mg | $3,120/5x25 mg
Structure
Dovitinib, Inhibitor (Cat# AAA3604393)
Full Name
Dovitinib
Purity
>98% (HPLC)
Pricing
$190/2 mg | $205/5 mg | $215/10 mg | $280/25 mg | $355/50 mg | $500/100 mg | $785/200 mg | $3,225/5x200 mg
Structure
ODM-203, Inhibitor (Cat# AAA5758498)
Full Name
ODM-203
Purity
98.77%
Pricing
$205/1 mg | $230/2 mg | $250/5 mg | $310/10 mg | $475/25 mg | $700/50 mg | $2,890/5x50 mg
Structure
ACTB-1003, Inhibitor (Cat# AAA3609265)
Full Name
ACTB-1003
Purity
>98% (HPLC)
Pricing
$265/2 mg | $330/5 mg | $455/10 mg | $985/50 mg | $1,450/100 mg | $6,230/5x100 mg
Structure
KW-2449, Inhibitor (Cat# AAA3600007)
Full Name
KW-2449
Purity
>98% (HPLC)
Pricing
$215/10 mg | $370/50 mg | $1,380/5x50 mg
Structure
S49076 hydrochloride, Inhibitor (Cat# AAA3601116)
Full Name
S49076 hydrochloride
Purity
>98% (HPLC)
Pricing
$225/2 mg | $245/5 mg | $305/10 mg | $395/25 mg | $560/50 mg | $895/100 mg | $3,735/5x100 mg
Structure
PD-166866, Inhibitor (Cat# AAA3607399)
Full Name
PD-166866
Purity
>98% (HPLC)
Pricing
$200/5 mg | $225/10 mg | $285/25 mg | $400/50 mg | $655/100 mg | $2,665/5x100 mg
Structure
AZD4547, Inhibitor (Cat# AAA3600175)
Full Name
AZD4547
Purity
>98% (HPLC)
Pricing
$190/5 mg | $200/10 mg | $215/25 mg | $245/50 mg | $280/100 mg | $335/200 mg | $1,210/5x200 mg
Structure
SU11274, Inhibitor (Cat# AAA3605499)
Full Name
SU11274
Purity
>98% (HPLC)
Pricing
$200/2 mg | $235/5 mg | $275/10 mg | $395/25 mg | $645/50 mg | $785/100 mg | $3,225/5x100 mg
Structure
PHA-680632, Inhibitor (Cat# AAA3604368)
Full Name
PHA-680632
Purity
>98% (HPLC)
Pricing
$315/10 mg | $915/50 mg | $3,820/5x50 mg
Structure
TAK-779, Inhibitor (Cat# AAA5758394)
Full Name
TAK-779
Purity
98.00%
Pricing
$215/2 mg | $240/5 mg | $305/10 mg | $430/25 mg | $585/50 mg | $310/1 mL (in DMSO) | $2,355/5x50 mg
Structure
Infigratinib, Inhibitor (Cat# AAA3606339)
Full Name
Infigratinib
Purity
>98% (HPLC)
Pricing
$200/5 mg | $210/10 mg | $240/25 mg | $265/50 mg | $340/100 mg | $505/200 mg | $2,000/5x200 mg
Structure
BLU9931, Inhibitor (Cat# AAA3602173)
Full Name
BLU9931
Purity
>98% (HPLC)
Pricing
$245/5 mg | $280/10 mg | $375/25 mg | $555/50 mg | $2,190/5x50 mg
Structure
FIIN-2, Inhibitor (Cat# AAA3607345)
Full Name
FIIN-2
Purity
>98% (HPLC)
Pricing
$190/2 mg | $225/5 mg | $280/10 mg | $390/25 mg | $605/50 mg | $2,430/5x50 mg
LY2874455, Inhibitor (Cat# AAA3601034)
Full Name
LY2874455
Purity
>98% (HPLC)
Pricing
$210/2 mg | $245/5 mg | $305/10 mg | $520/25 mg | $655/100 mg | $2,665/5x100 mg
Structure
Ponatinib, Inhibitor (Cat# AAA3606750)
Full Name
Ponatinib
Purity
>98% (HPLC)
Pricing
$190/10 mg | $205/50 mg | $235/100 mg | $265/200 mg | $910/5x200 mg
Structure
Dovitinib Dilactic Acid, Inhibitor (Cat# AAA3607612)
Full Name
Dovitinib Dilactic Acid
Purity
>98% (HPLC)
Pricing
$190/2 mg | $215/5 mg | $245/10 mg | $335/25 mg | $480/50 mg | $690/100 mg | $2,825/5x100 mg
Structure
Nintedanib, Inhibitor (Cat# AAA3605492)
Full Name
Nintedanib
Purity
>98% (HPLC)
Pricing
$190/5 mg | $200/10 mg | $205/50 mg | $230/100 mg | $265/200 mg | $920/5x200 mg
Structure
Sorafenib tosylate, Inhibitor (Cat# AAA3604579)
Full Name
Sorafenib tosylate
Purity
>98% (HPLC)
Pricing
$175/5 mg | $190/10 mg | $205/50 mg | $210/100 mg | $230/200 mg | $760/5x200 mg
Derazantinib, Inhibitor (Cat# AAA5764480)
Full Name
Derazantinib
Purity
99.95%
Pricing
$315/2 mg | $380/5 mg | $885/25 mg | $3,725/5x25 mg
Structure
SSR128129E, Inhibitor (Cat# AAA3607604)
Full Name
SSR128129E
Purity
>98% (HPLC)
Pricing
$190/2 mg | $210/5 mg | $250/10 mg | $335/25 mg | $420/50 mg | $660/100 mg | $2,680/5x100 mg
Structure
BLU-554, Inhibitor (Cat# AAA3602606)
Full Name
BLU-554
Purity
>98% (HPLC)
Pricing
$240/2 mg | $305/5 mg | $380/10 mg | $715/25 mg | $2,935/5x25 mg
Structure
PD173074, Inhibitor (Cat# AAA3603497)
Full Name
PD173074
Purity
>98% (HPLC)
Pricing
$200/10 mg | $265/50 mg | $335/100 mg | $485/200 mg | $1,905/5x200 mg
Structure
Danusertib, Inhibitor (Cat# AAA3606070)
Full Name
Danusertib
Purity
>98% (HPLC)
Pricing
$210/2 mg | $240/5 mg | $310/10 mg | $445/25 mg | $640/50 mg | $2,600/5x50 mg
ASP5878, Inhibitor (Cat# AAA3845053)
Full Name
ASP5878
Purity
>98%
Pricing
$515/5 mg | $860/10 mg | $2,440/50 mg | $4,805/100 mg
S49076, Inhibitor (Cat# AAA3845837)
Full Name
S49076
Purity
>98%
Pricing
$150/2 mg | $210/5 mg | $340/10 mg | $910/50 mg | $4,035/5x50 mg
Chemical Structure
Debio-1347, Inhibitor (Cat# AAA3840356)
Full Name
Debio-1347 (CH5183284)
Purity
>98%
Pricing
$130/5 mg | $165/10 mg | $230/25 mg | $985/5x25 mg
Tyrosine kinase-IN-1, Inhibitor (Cat# AAA3610192)
Full Name
Tyrosine kinase-IN-1
Purity
>98% (HPLC)
Pricing
$400/5 mg | $570/10 mg | $905/25 mg | $3,785/5x25 mg
Structure
TSU-68, Inhibitor (Cat# AAA3603745)
Full Name
TSU-68
Purity
>98% (HPLC)
Pricing
$200/5 mg | $225/10 mg | $310/25 mg | $445/50 mg | $680/100 mg | $2,785/5x100 mg
Structure
PHA-665752, Inhibitor (Cat# AAA3604590)
Full Name
PHA-665752
Purity
>98% (HPLC)
Pricing
$200/5 mg | $225/10 mg | $305/25 mg | $425/50 mg | $650/100 mg | $890/200 mg | $3,720/5x200 mg
