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11 results for "Brk inhibitor" - showing 1-11
Structure
Ibrutinib, Inhibitor (Cat# AAA575412)
Full Name
Ibrutinib (PCI-32765)
Purity
99.79%
Pricing
$185/5 mg | $200/10 mg | $205/50 mg | $215/100 mg | $235/200 mg | $200/1 mL (in DMSO) | $795/5x200 mg
Testing Data
(PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-RafV600E kinase compared with a broad spectrum of other kinases (IC50:B-Raf=160 nM, BRK=130 nM, other kinases >1000nM), and potent cytotoxic effects are also exclusive to cells bearing the V600E allele (GI5010 uM). [1]Consistent with the high degree of selectivity, ERK phosphorylation is potently inhibited by PLX4720 in B-RafV600E -bearing tumor cell lines but not in cells lacking oncogenic B-Raf. [1]In B-RafV600E -dependent tumor xenograft models, orally dosed PLX4720 causes significant tumor growth delays, including tumor regressions, without evidence of toxicity. [1])
PLX-4720, Inhibitor (Cat# AAA8506422)
Full Name
PLX-4720
Purity
>99%
Pricing
$295/5 mg | $1,255/5x5 mg
Structure
AZ7550 Mesylate, Inhibitor (Cat# AAA5754248)
Full Name
AZ7550 Mesylate
Purity
98.00%
Pricing
$370/5 mg | $505/10 mg | $1,985/5x10 mg
Structure
Ibrutinib, Inhibitor (Cat# AAA3606699)
Full Name
Ibrutinib
Purity
>98% (HPLC)
Pricing
$185/5 mg | $190/10 mg | $200/50 mg | $210/100 mg | $230/200 mg | $750/5x200 mg
Structure
AZ7550 hydrochloride, Inhibitor (Cat# AAA5754247)
Full Name
AZ7550 hydrochloride
Purity
98.00%
Pricing
$370/5 mg | $505/10 mg | $1,985/5x10 mg
SDS-Page
(Recombinant PTK6 protein gel 10% SDS-PAGE with Coomassie blue staining MW: 53 kDa Purity: >95%)
PTK6, Recombinant Protein (Cat# AAA389383)
Full Name
Recombinant PTK6 protein
Gene Names
PTK6; BRK
Pricing
$565/0.02 mg | $4,215/1 mg | $18,905/5x1 mg
Structure
Structure
PLX-4720, Inhibitor (Cat# AAA3606589)
Full Name
PLX-4720
Purity
>98% (HPLC)
Pricing
$190/5 mg | $200/10 mg | $230/25 mg | $250/50 mg | $310/100 mg | $450/200 mg | $1,745/5x200 mg
Structure
AVL-292, Inhibitor (Cat# AAA3600735)
Full Name
AVL-292
Purity
>98% (HPLC)
Pricing
$190/2 mg | $205/5 mg | $230/10 mg | $325/25 mg | $370/50 mg | $515/100 mg | $2,045/5x100 mg
Structure
Vemurafenib, Inhibitor (Cat# AAA3606587)
Full Name
Vemurafenib
Purity
>98% (HPLC)
Pricing
$190/10 mg | $210/50 mg | $235/100 mg | $300/200 mg | $1,045/5x200 mg
Chemical Structure
Tilfrinib, Inhibitor (Cat# AAA3841384)
Full Name
Tilfrinib
Purity
>98%
Pricing
$180/5 mg | $260/10 mg | $885/50 mg | $3,920/5x50 mg
