AZ7550 Mesylate, Inhibitor | AZ7550, inhibitor

AZ7550 Mesylate

Cat. Num. AAA5754248

• Purity: 98.00%
• Synonyms: AZ7550 Mesylate; AZ7550 trimesylate salt; AZ7550; inhibitor

• Purity/Purification: 98.00%
• Form/Format: Solid. Powder

• Solubility: DMSO: 25mg/mL (32.30mM) Need ultrasonic; (<1mg/ml refers to the product slightly soluble or insoluble)
• Formula: C30H43N7O11S3
• SMILES: CN1C=C(C2=NC(NC3=CC(NC(C=C)=O)=C(N(CCNC)C)C=C3OC)=NC=C2)C4=CC=CC=C41.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O
• Target & IC50: IGF1R: ic50 1.6uM; MLK1: ic50 88nM; ACK1: ic50 156nM; ErbB4: ic50 195nM; MNK2: ic50 228nM; FLT3: ic50 302nM; ALK: ic50 420nM; FES: ic50 449nM; IRR: ic50 840nM; BRK: ic50 843nM; BLK: ic50 977nM; FAK: ic50 995nM; Ins R: ic50 1256nM; TEC: ic50 1317nM; FLT4: ic50 1784nM; PYK2: ic50 2288nM
• In Vitro: AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537nM).
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent

Structure

Related Product Information for AZ7550, inhibitor

AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6uM).

Product Categories/Family for AZ7550, inhibitor

MAPK; MLK

References

Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.
Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57(20):8249-67.