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627 results for " mTOR inhibitor" - showing 1-50
Structure
LY294002, Inhibitor (Cat# AAA575724)
Full Name
LY294002
Purity
99.93%
Pricing
$175/5 mg | $185/10 mg | $205/50 mg | $215/100 mg | $245/200 mg | $200/1 mL (in DMSO) | $840/5x200 mg
Structure
3-Methyladenine (3-MA), Inhibitor (Cat# AAA575485)
Full Name
3-Methyladenine (3-MA)
Purity
99.51%
Pricing
$185/25 mg | $205/50 mg | $230/100 mg | $380/500 mg | $275/200 mg | $195/1 mL (in DMSO) | $1,435/5x500 mg
Structure
Rapamycin, Inhibitor (Cat# AAA575148)
Full Name
Rapamycin (Sirolimus)
Purity
99.23%
Pricing
$185/25 mg | $205/50 mg | $215/100 mg | $330/500 mg | $250/200 mg | $200/1 mL (in DMSO) | $1,225/5x500 mg
Testing Data
(Staining of human peripheral blood lymphocytes with Mouse anti Human CD299: Azide Free (MBS210211))
CD229, Monoclonal Antibody (Cat# AAA212512)
Full Name
MOUSE ANTI HUMAN CD229
Gene Names
LY9; hly9; mLY9; CD229; SLAMF3
Applications
FC/FACS, IP
Pricing
$525/0.2 mg | $2,210/5x0.2 mg
mTOR, Polyclonal Antibody (Cat# AAA194307)
Full Name
mTOR Polyclonal Antibody
Applications
Western Blot, Immunoprecipitation
Pricing
$515/0.1 mg | $2,270/5x0.1 mg
mTOR, Polyclonal Antibody (Cat# AAA194308)
Full Name
mTOR Polyclonal Antibody
Applications
Western Blot, Immunoprecipitation
Pricing
$515/0.1 mg | $2,270/5x0.1 mg
Western Blot (WB)
(Western blot analysis of extracts from NIH/3T3 cells, untreated or PDGF-treated (100ng/ml, 20 min), using MBS631700 S6 Phosphorylated Ribosomal protein (Ser235/236) (upper) or S6 Ribosomal Protein MBS631700 (lower).)
S6 Ribosomal Protein, Monoclonal Antibody (Cat# AAA631700)
Full Name
S6 Ribosomal Protein, phosphorylated (Ser235/236)
Reactivity
Human, Mouse, Rat
Applications
WB, IP, IHC
Purity
Purified
Purified
Purified
Pricing
$665/0.1 mL | $2,980/5x0.1 mL
Structure
Duvelisib, Inhibitor (Cat# AAA575674)
Full Name
Duvelisib (IPI-145, INK1197)
Purity
99.4%
Pricing
$190/2 mg | $210/5 mg | $230/10 mg | $255/25 mg | $290/50 mg | $370/100 mg | $210/1 mL (in DMSO) | $1,400/5x100 mg
Structure
PF-4708671, Inhibitor (Cat# AAA575813)
Full Name
PF-4708671
Purity
99.7%
Pricing
$205/5 mg | $215/10 mg | $250/25 mg | $290/50 mg | $395/100 mg | $225/1 mL (in DMSO) | $1,500/5x100 mg
Structure
Torin 1, Inhibitor (Cat# AAA578620)
Full Name
Torin 1
Purity
98.3%
Pricing
$195/2 mg | $215/5 mg | $250/10 mg | $390/25 mg | $525/50 mg | $785/100 mg | $3,260/5x100 mg
Structure
AICAR, Inhibitor (Cat# AAA575260)
Full Name
AICAR (Acadesine)
Purity
99.2%
Pricing
$185/25 mg | $195/50 mg | $215/100 mg | $255/200 mg | $195/1 mL (in DMSO) | $870/5x200 mg
Western Blot (WB)
(Western Blot analysis of extracts from NIH/3T3 cells, untreated or treated with serum in the presence of the indicated concentrations of Rapamycin)
Rapamycin, Inhibitor (Cat# AAA655453)
Full Name
Rapamycin (FRAP, mTOR Inhibitor, Sirolimus)
Purity
Highly Purified
Highly purified
Highly purified
Pricing
$180/10 mg | $435/50 mg | $600/250 mg | $870/500 mg | $3,910/5x500 mg
Chemical Structure
(Chemical structure of Rapamycin (SIH-212), a mTOR inhibitor. CAS #: 53123-88-9. Molecular Formula: C51H79NO13 . Molecular Weight: 914.18 g/mol.)
Rapamycin, Small Molecule (Cat# AAA807957)
Full Name
Rapamycin
Purity
>98%
Pricing
$250/5 mg | $440/25 mg | $1,760/5x25 mg | $895/5x5 mg
FK506 Binding Protein 12, Recombinant Protein (Cat# AAA636311)
Full Name
FK506 Binding Protein 12, Recombinant, Human (FKBP12, FK506 BP1A)
Gene Names
FKBP1A; FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A
Purity
Highly Purified
0.9
0.9
Pricing
$740/0.2 mg | $3,320/5x0.2 mg
Structure
NU7441, Inhibitor (Cat# AAA578838)
Full Name
NU7441
Purity
99.87%
Pricing
$185/2 mg | $205/5 mg | $235/10 mg | $315/25 mg | $405/50 mg | $525/100 mg | $765/200 mg | $3,180/5x200 mg
Structure
BKM120, Inhibitor (Cat# AAA577126)
Full Name
BKM120 (NVP-BKM120, Buparlisib)
Purity
97.22%
Pricing
$200/5 mg | $215/10 mg | $240/50 mg | $265/100 mg | $350/200 mg | $200/1 mL (in DMSO) | $1,305/5x200 mg
Structure
XL388, Inhibitor (Cat# AAA578605)
Full Name
XL388
Purity
99.4%
Pricing
$205/1 mg | $240/2 mg | $295/5 mg | $350/10 mg | $615/25 mg | $870/50 mg | $1,145/100 mg | $295/1 mL (in DMSO) | $4,880/5x100 mg
Structure
WYE-354, Inhibitor (Cat# AAA579264)
Full Name
WYE-354
Purity
99.6%
Pricing
$180/2 mg | $195/5 mg | $225/10 mg | $290/25 mg | $405/50 mg | $500/100 mg | $610/200 mg | $200/1 mL (in DMSO) | $2,465/5x200 mg
Molecular Structure
AR-A014418, Inhibitor (Cat# AAA515047)
Full Name
AR-A014418
Purity
>98% (TLC: 10% CH3OH in CH2Cl2; Rf=0.51); NMR (conforms)
Pricing
$215/5 mg | $405/25 mg | $1,605/5x25 mg
Testing Data
()
Rapamycin, seco, Sodium Salt, Biochemical (Cat# AAA6081651)
Full Name
Rapamycin, seco, Sodium Salt (FRAP, mTOR Inhibitor, Sirolimus)
Pricing
$610/10 mg | $2,730/5x10 mg
Structure
Gedatolisib, Inhibitor (Cat# AAA577271)
Full Name
Gedatolisib (PF-05212384, PKI-587)
Purity
99.0%
Pricing
$205/2 mg | $240/5 mg | $290/10 mg | $395/25 mg | $560/50 mg | $885/100 mg | $3,710/5x100 mg
Structure
Ridaforolimus, Inhibitor (Cat# AAA578885)
Full Name
Ridaforolimus
Purity
95.0%
Pricing
$205/5 mg | $230/10 mg | $300/25 mg | $420/50 mg | $630/100 mg | $985/200 mg | $305/1 mL (in DMSO) | $4,165/5x200 mg
mTOR Inhibitor, Ku-0063794, Biochemical (Cat# AAA6064948)
Full Name
mTOR Inhibitor, Ku-0063794 (rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol)
Purity
Highly Purified
~98% (HPLC)
~98% (HPLC)
Pricing
$375/1 mg | $710/5 mg | $3,195/5x5 mg
Structure
WYE-687, Inhibitor (Cat# AAA579265)
Full Name
WYE-687
Purity
98.0%
Pricing
$205/1 mg | $240/2 mg | $315/10 mg | $560/25 mg | $700/50 mg | $365/1mL*10mM (in DMSO) | $2,875/5x50 mg
AKT2, Polyclonal Antibody (Cat# AAA1489636)
Full Name
Rabbit Anti Human AKT2 PolyClonal Antibody
Gene Names
AKT2; PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
Purity
Affinity Purification
Pricing
$325/0.1 mL | $1,465/5x0.1 mL
Testing Data
(PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 uM for p110alpha, p110beta, p110delta, p110gamma and DNA-PK, respectively. PP242 inhibits other PI 3-Kinases only at much higher concentrations. PP242, but not rapamycin, causes death of mouse and human leukemia cells. In vivo, PP242 delays leukemia onset and augments the effects of the current front-line tyrosine kinase inhibitors more effectively than does rapamycin. PP242 was also more effective than rapamycin in achieving cytoreduction and apoptosis in multiple myeloma cells. In addition, PP242 was an effective agent against primary multiple myeloma cells in vitro and growth of 8226 cells in mice. Knockdown of the TORC2 complex protein, rictor, was deleterious to multiple myeloma cells further supporting TORC2 as the critical target for PP242. [1][2][3])
Structure
Tideglusib, Inhibitor (Cat# AAA575056)
Full Name
Tideglusib
Purity
99.84%
Pricing
$195/5 mg | $215/10 mg | $235/25 mg | $250/50 mg | $330/100 mg | $490/200 mg | $195/1 mL (in DMSO) | $1,925/5x200 mg
Structure
MTX-211, Inhibitor (Cat# AAA5750105)
Full Name
MTX-211
Purity
99.5%
Pricing
$240/1 mg | $305/2 mg | $445/5 mg | $610/10 mg | $1,080/25 mg | $1,595/50 mg | $2,250/100 mg | $445/1 mL (in DMSO) | $9,855/5x100 mg
Structure
A 769662, Inhibitor (Cat# AAA576261)
Full Name
A 769662
Purity
99.6%
Pricing
$195/2 mg | $205/5 mg | $215/10 mg | $290/25 mg | $385/50 mg | $625/100 mg | $205/1 mL (in DMSO) | $2,540/5x100 mg
RPS6KB1, Polyclonal Antibody (Cat# AAA1491509)
Full Name
Rabbit Anti Human RPS6KB1 PolyClonal Antibody
Gene Names
RPS6KB1; S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
Purity
Affinity Purification
Pricing
$325/0.1 mL | $1,465/5x0.1 mL
Structure
A66, Inhibitor (Cat# AAA575616)
Full Name
A66
Purity
99.33%
Pricing
$190/1 mg | $200/2 mg | $235/5 mg | $270/10 mg | $400/25 mg | $240/1 mL (in DMSO) | $1,530/5x25 mg
Molecular Structure
SB-202190, Inhibitor (Cat# AAA515060)
Full Name
SB-202190
Purity
>98% (TLC: 10% CH3OH in CH2Cl2, Rf=0.25); NMR (Conforms)
Pricing
$225/5 mg | $510/25 mg | $2,065/5x25 mg
Testing Data
(GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kalpha (0.4 nM) and PI3Kbeta (0.6 nM) and shows low nanomolar activity towards gamma(5 nM),delta(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1])
Structure
GDC-0349, Inhibitor (Cat# AAA579052)
Full Name
GDC-0349
Purity
98.0%
Pricing
$205/2 mg | $240/5 mg | $315/10 mg | $490/25 mg | $245/1mL*10mM (in DMSO) | $1,930/5x25 mg
Structure
TG100-115, Inhibitor (Cat# AAA576888)
Full Name
TG100-115
Purity
99.0%
Pricing
$205/1 mg | $215/2 mg | $225/5 mg | $275/10 mg | $375/25 mg | $525/50 mg | $240/1 mL (in DMSO) | $2,100/5x50 mg
Structure
AZD-5363, Inhibitor (Cat# AAA576509)
Full Name
AZD-5363
Purity
99.48%
Pricing
$185/1 mg | $200/2 mg | $210/5 mg | $240/10 mg | $300/25 mg | $375/50 mg | $545/100 mg | $210/1 mL (in DMSO) | $2,180/5x100 mg
Structure
Antrapurol, Inhibitor (Cat# AAA577416)
Full Name
Antrapurol
Purity
98.0%
Pricing
$175/25 mg | $185/50 mg | $195/100 mg | $215/200 mg | $195/1 mL (in DMSO) | $705/5x200 mg
Structure
ETP46464, Inhibitor (Cat# AAA576593)
Full Name
ETP46464
Purity
99.56%
Pricing
$190/1 mg | $205/2 mg | $225/5 mg | $255/10 mg | $350/25 mg | $520/50 mg | $830/100 mg | $230/1 mL (in DMSO) | $3,475/5x100 mg
Structure
OTSSP167, Inhibitor (Cat# AAA576014)
Full Name
OTSSP167
Purity
98.8%
Pricing
$260/2 mg | $295/5 mg | $370/10 mg | $690/25 mg | $2,835/5x25 mg
Structure
Torkinib, Inhibitor (Cat# AAA576137)
Full Name
Torkinib (PP242)
Purity
99.23%
Pricing
$185/2 mg | $200/5 mg | $215/10 mg | $255/25 mg | $270/50 mg | $345/100 mg | $450/200 mg | $200/1 mL (in DMSO) | $1,750/5x200 mg
Structure
BYL-719, Inhibitor (Cat# AAA576012)
Full Name
BYL-719(Alpelisib)
Purity
99.25%
Pricing
$185/1 mg | $195/2 mg | $205/5 mg | $215/10 mg | $235/25 mg | $240/50 mg | $290/100 mg | $745/500 mg | $395/200 mg | $205/1 mL (in DMSO) | $3,085/5x500 mg
Testing Data
(PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 uM for p110alpha, p110beta, p110delta, p110gamma, DNA-PK, mTOR and PDGFR, respectively. PP121 also inhibits Abl, Hck, Src,Src(T338I), VEGFR2, EGFR EphB4 with IC50 of 0.018, 0.008, 0.014, 0.22, 0.012, 0.26, 0.19 uM, respectively. PP121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP121 blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor. PP121 achieves its dual potency by targeting a residue (Glu310 in Src) that has been structurally conserved between kinase families. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in these cells. [1])
Structure
PIK-93, Inhibitor (Cat# AAA576834)
Full Name
PIK-93
Purity
99.83%
Pricing
$195/2 mg | $230/5 mg | $280/10 mg | $420/25 mg | $230/1 mL (in DMSO) | $1,630/5x25 mg
Structure
AS-605240, Inhibitor (Cat# AAA577366)
Full Name
AS-605240
Purity
97.0%
Pricing
$195/5 mg | $205/10 mg | $265/25 mg | $335/50 mg | $405/100 mg | $530/200 mg | $2,110/5x200 mg
Structure
KU55933, Inhibitor (Cat# AAA576517)
Full Name
KU55933
Purity
98.19%
Pricing
$195/5 mg | $210/10 mg | $245/25 mg | $300/50 mg | $400/100 mg | $200/1 mL (in DMSO) | $1,525/5x100 mg
Structure
AZD8055, Inhibitor (Cat# AAA575015)
Full Name
AZD8055
Purity
99.69%
Pricing
$200/5 mg | $205/10 mg | $225/25 mg | $235/50 mg | $290/100 mg | $395/200 mg | $200/1 mL (in DMSO) | $1,490/5x200 mg
Structure
BML-275, Inhibitor (Cat# AAA577477)
Full Name
BML-275
Purity
98.77%
Pricing
$205/5 mg | $230/10 mg | $325/25 mg | $385/50 mg | $605/100 mg | $825/200 mg | $3,450/5x200 mg
Structure
Tacrolimus, Inhibitor (Cat# AAA576529)
Full Name
Tacrolimus (FK506)
Purity
99.94%
Pricing
$195/10 mg | $205/25 mg | $215/50 mg | $245/100 mg | $370/500 mg | $285/200 mg | $1,400/5x500 mg
Structure
INK 128, Inhibitor (Cat# AAA576778)
Full Name
INK 128 (MLN0128)
Purity
98.0%
Pricing
$205/2 mg | $225/5 mg | $245/10 mg | $315/25 mg | $385/50 mg | $225/1 mL (in DMSO) | $1,470/5x50 mg
Structure
CNX-1351, Inhibitor (Cat# AAA575736)
Full Name
CNX-1351
Purity
99.7%
Pricing
$225/2 mg | $250/5 mg | $335/10 mg | $545/25 mg | $790/50 mg | $275/1 mL (in DMSO) | $3,280/5x50 mg
