Testing Data
(GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kalpha (0.4 nM) and PI3Kbeta (0.6 nM) and shows low nanomolar activity towards gamma(5 nM),delta(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1])
GSK1059615, inhibitor
GSK1059615
Synonyms
GSK1059615; inhibitor
Solubility
DMSO >=5 mg/mL - Water <1 mg/mL - Ethanol <1 mg/mL
Formula
C18H11N3O2S
CAS Number
958852-01-2
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
(GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kalpha (0.4 nM) and PI3Kbeta (0.6 nM) and shows low nanomolar activity towards gamma(5 nM),delta(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1])
Testing Data
(GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kalpha (0.4 nM) and PI3Kbeta (0.6 nM) and shows low nanomolar activity towards gamma(5 nM),delta(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1])
Related Product Information for GSK1059615, inhibitor
GSK1059615 is a pan-PI3K reversible inhibitor with sub-nanomolar IC50 for PI3Kalpha (0.4 nM) and PI3Kbeta (0.6 nM) and shows low nanomolar activity towards gamma (5 nM), delta(2 nM) and mTOR(12 nM). GSK1059615 inhibits PI3K pathway in cells inducing G1 arrest, although apopto-sis was observed in a subset of cell lines. Breast tumor cells seem to be more sensitive to this compound. In xenograft mice, a complete tumor inhibition and regression were observed together with an increase in plasma insulin levels. [1]
Product Categories/Family for GSK1059615, inhibitor
References
Novel inhibitors of the PI3K family Informa healthcare September 2009; 1265-1277 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The GSK1059615 (Catalog #AAA8506343) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK1059615, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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