E3 ubiquitin-protein ligase RNF34 (RNF34) Recombinant Protein | RNF34 recombinant protein

Recombinant Bovine E3 ubiquitin-protein ligase RNF34 (RNF34)

Cat. Num. AAA1376748

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase RNF34 (RNF34); Recombinant Bovine E3 ubiquitin-protein ligase RNF34 (RNF34); RNF34 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-375, full length protein
• Sequence: MKAGATSMWASCCGLLNEVMGTGAVRGQQSGFAGGTGPFRFTPNSDFSAYPPASAEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHRLGSEDDLDTSSLNSSRSQTSSFFTHSFFSNYTAPSATASSFQGELMGGDRTLGSGALAQEPSEIASANTEDDEDDDDDDDDDDDDDEENLEDRTPGLTKKRVRASLSDLSSLEDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS
• Sequence Length: 375

• Species: Bovine
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for RNF34 recombinant protein

This protein contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3
hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 62460416
• NCBI GeneID: 506764
• NCBI Accession #: NP_001014858.1
• NCBI GenBank Nucleotide #: NM_001014858.1
• UniProt Accession #: Q5E9J6
• Molecular Weight: 41,788 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF34
• NCBI Official Synonym Full Names: ring finger protein 34
• NCBI Official Symbol: RNF34
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF34
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF34
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF34

Uniprot Description

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.